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Article

Discriminant Analysis of Main Prognostic Factors Associated with Hemodynamically Significant PDA: Apgar Score, Silverman–Anderson Score, and NT-Pro-BNP Level

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Department of Pediatric Infectious Diseases, Perm State Medical University, 614990 Perm, Russia
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Federal Center of Cardiovascular Surgery, 614990 Perm, Russia
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Department of Computational Mathematics, Mechanics, and Biomechanics, Perm National Research Polytechnic University, 614990 Perm, Russia
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Department of Pediatrics, Perm State Medical University, 614990 Perm, Russia
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Department of the Intermediate Level and Hospital Pediatrics, Perm State Medical University, 614990 Perm, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Emmanuel Androulakis
J. Clin. Med. 2021, 10(16), 3729; https://doi.org/10.3390/jcm10163729
Received: 3 July 2021 / Revised: 2 August 2021 / Accepted: 17 August 2021 / Published: 22 August 2021
Hemodynamically significant patent ductus arteriosus (hsPDA) in premature newborns is associated with a risk of PDA-related morbidities. Classification into risk groups may have a clinical utility in cases of suspected hsPDA to decrease the need for echocardiograms and unnecessary treatment. This prospective observational study included 99 premature newborns with extremely low body weight, who had an echocardiogram performed within the first three days of life. Discriminant analysis was utilized to find the best combination of prognostic factors for evaluation of hsPDA. We used binary logistic regression analysis to predict the relationship between parameters and hsPDA. The cohort’s mean and standard deviation gestational age was 27.6 ± 2.55 weeks, the mean birth weight was 1015 ± 274 g. Forty-six (46.4%) infants had a PDA with a mean diameter of 2.78 mm. Median NT-pro-BNP levels were 17,600 pg/mL for infants with a PDA and 2773 pg/mL in the non-hsPDA group. The combination of prognostic factors of hsPDA in newborns of extremely low body weight on the third day of life was determined: NT-pro-BNP, Apgar score, Silverman–Anderson score (Se = 82%, Sp = 88%). A cut-off value of NT-pro-BNP of more than 8500 pg/mL can predict hsPDA (Se = 84%, Sp = 86%). View Full-Text
Keywords: premature newborns; hemodynamically significant patent ductus arteriosus; Apgar score; Silverman–Anderson score; NT-pro-BNP premature newborns; hemodynamically significant patent ductus arteriosus; Apgar score; Silverman–Anderson score; NT-pro-BNP
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MDPI and ACS Style

Permyakova, A.V.; Porodikov, A.; Kuchumov, A.G.; Biyanov, A.; Arutunyan, V.; Furman, E.G.; Sinelnkov, Y.S. Discriminant Analysis of Main Prognostic Factors Associated with Hemodynamically Significant PDA: Apgar Score, Silverman–Anderson Score, and NT-Pro-BNP Level. J. Clin. Med. 2021, 10, 3729. https://doi.org/10.3390/jcm10163729

AMA Style

Permyakova AV, Porodikov A, Kuchumov AG, Biyanov A, Arutunyan V, Furman EG, Sinelnkov YS. Discriminant Analysis of Main Prognostic Factors Associated with Hemodynamically Significant PDA: Apgar Score, Silverman–Anderson Score, and NT-Pro-BNP Level. Journal of Clinical Medicine. 2021; 10(16):3729. https://doi.org/10.3390/jcm10163729

Chicago/Turabian Style

Permyakova, Anna V., Artem Porodikov, Alex G. Kuchumov, Alexey Biyanov, Vagram Arutunyan, Evgeniy G. Furman, and Yuriy S. Sinelnkov 2021. "Discriminant Analysis of Main Prognostic Factors Associated with Hemodynamically Significant PDA: Apgar Score, Silverman–Anderson Score, and NT-Pro-BNP Level" Journal of Clinical Medicine 10, no. 16: 3729. https://doi.org/10.3390/jcm10163729

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