Next Article in Journal
The Impact of SARS-CoV-2 Infection on Fertility and Female and Male Reproductive Systems
Next Article in Special Issue
Right Ventricular Structure and Function in Young Adults Born Preterm at Very Low Birth Weight
Previous Article in Journal
Postnatal Repair of Open Neural Tube Defects: A Single Center with 90-Month Interdisciplinary Follow-Up
Previous Article in Special Issue
Effect of Preterm Birth on Cardiac and Cardiomyocyte Growth and the Consequences of Antenatal and Postnatal Glucocorticoid Treatment
Article

Safety, Feasibility, and Impact of Enalapril on Cardiorespiratory Physiology and Health in Preterm Infants with Systemic Hypertension and Left Ventricular Diastolic Dysfunction

1
Division of Neonatology, Department of Pediatrics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
2
Division of Pediatric Nephrology, Department of Pediatrics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
3
Department of Internal Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
*
Author to whom correspondence should be addressed.
Amy H. Stanford and Melanie Reyes shared equal responsibility as first author.
Academic Editor: Adam J. Lewandowski
J. Clin. Med. 2021, 10(19), 4519; https://doi.org/10.3390/jcm10194519
Received: 2 August 2021 / Revised: 23 September 2021 / Accepted: 25 September 2021 / Published: 29 September 2021
Neonatal hypertension has been increasingly recognized in premature infants with bronchopulmonary dysplasia (BPD); of note, a sub-population of these infants may have impaired left ventricular (LV) diastolic function, warranting timely treatment to minimize long term repercussions. In this case series, enalapril, an angiotensin-converting enzyme (ACE) inhibitor, was started in neonates with systemic hypertension and echocardiography signs of LV diastolic dysfunction. A total of 11 patients were included with birth weight of 785 ± 239 grams and gestational age of 25.3 (24, 26.1) weeks. Blood pressure improvement was noticed within 2 weeks of treatment. Improvement in LV diastolic function indices were observed with a reduction in Isovolumic Relaxation Time (IVRT) from 63.1 ± 7.2 to 50.9 ± 7.4 msec and improvement in the left atrium size indexed to aorta (LA:Ao) from1.73 (1.43, 1.88) to 1.23 (1.07, 1.29). Neonatal systemic hypertension is often underappreciated in ex-preterm infants and may be associated with important maladaptive cardiac changes with long term implications. It is biologically plausible that identifying and treating LV diastolic dysfunction in neonates with systemic hypertension may have a positive modulator effect on cardiovascular health in childhood and beyond. View Full-Text
Keywords: left ventricular diastolic dysfunction; systemic hypertension; bronchopulmonary dysplasia; angiotensin-converting enzyme inhibitor; enalapril; cardiac lung disease left ventricular diastolic dysfunction; systemic hypertension; bronchopulmonary dysplasia; angiotensin-converting enzyme inhibitor; enalapril; cardiac lung disease
Show Figures

Figure 1

MDPI and ACS Style

Stanford, A.H.; Reyes, M.; Rios, D.R.; Giesinger, R.E.; Jetton, J.G.; Bischoff, A.R.; McNamara, P.J. Safety, Feasibility, and Impact of Enalapril on Cardiorespiratory Physiology and Health in Preterm Infants with Systemic Hypertension and Left Ventricular Diastolic Dysfunction. J. Clin. Med. 2021, 10, 4519. https://doi.org/10.3390/jcm10194519

AMA Style

Stanford AH, Reyes M, Rios DR, Giesinger RE, Jetton JG, Bischoff AR, McNamara PJ. Safety, Feasibility, and Impact of Enalapril on Cardiorespiratory Physiology and Health in Preterm Infants with Systemic Hypertension and Left Ventricular Diastolic Dysfunction. Journal of Clinical Medicine. 2021; 10(19):4519. https://doi.org/10.3390/jcm10194519

Chicago/Turabian Style

Stanford, Amy H., Melanie Reyes, Danielle R. Rios, Regan E. Giesinger, Jennifer G. Jetton, Adrianne R. Bischoff, and Patrick J. McNamara 2021. "Safety, Feasibility, and Impact of Enalapril on Cardiorespiratory Physiology and Health in Preterm Infants with Systemic Hypertension and Left Ventricular Diastolic Dysfunction" Journal of Clinical Medicine 10, no. 19: 4519. https://doi.org/10.3390/jcm10194519

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop