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Article

Safety, Fear and Neuromuscular Responses after a Resisted Knee Extension Performed to Failure in Patients with Severe Haemophilia

1
Exercise Intervention for Health Research Group (EXINH-RG), Department of Physiotherapy, University of Valencia, 46010 Valencia, Spain
2
National Research Centre for the Working Environment, 2100 Copenhagen, Denmark
3
Physiotherapy in Motion Multispeciality Research Group (PTinMOTION), Department of Physiotherapy, University of Valencia, 46010 Valencia, Spain
4
Intelligent Data Analysis Laboratory, University of Valencia, 46010 Valencia, Spain
5
Haemostasis and Thrombosis Unit, Universitary and Polytechnic Hospital La Fe, 46010 Valencia, Spain
6
Laboratory of Clinical Biomechanics, Department of Physical Therapy, Faculty of Medicine, University of Chile, Santiago 8380453, Chile
7
Sport Sciences, Department of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark
*
Author to whom correspondence should be addressed.
Academic Editors: Massimo Morfini and Angelo Claudio Molinari
J. Clin. Med. 2021, 10(12), 2587; https://doi.org/10.3390/jcm10122587
Received: 30 March 2021 / Revised: 28 May 2021 / Accepted: 8 June 2021 / Published: 11 June 2021
(This article belongs to the Special Issue Haemophilia: Current Treatment and Challenges)
Background: low–moderate intensity strength training to failure increases strength and muscle hypertrophy in healthy people. However, no study assessed the safety and neuromuscular response of training to failure in people with severe haemophilia (PWH). The purpose of the study was to analyse neuromuscular responses, fear of movement, and possible adverse effects in PWH, after knee extensions to failure. Methods: twelve severe PWH in prophylactic treatment performed knee extensions until failure at an intensity of five on the Borg CR10 scale. Normalised values of amplitude (nRMS) and neuromuscular fatigue were determined using surface electromyography for the rectus femoris, vastus medialis, and vastus lateralis. After the exercise, participants were asked about their perceived change in fear of movement, and to report any possible adverse effects. Results: Patients reported no adverse effects or increased fear. The nRMS was maximal for all the muscles before failure, the median frequency decreased, and wavelet index increased during the repetitions. The vastus lateralis demonstrated a higher maximum nRMS threshold and earlier fatigue, albeit with a lower and more progressive overall fatigue. Conclusions: severe PWH with adequate prophylactic treatment can perform knee extensions to task failure using a moderate intensity, without increasing fear of movement, or adverse effects. View Full-Text
Keywords: EMG; neuromuscular fatigue; quadriceps; arthropathy; resistance training; kinesiophobia EMG; neuromuscular fatigue; quadriceps; arthropathy; resistance training; kinesiophobia
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MDPI and ACS Style

Calatayud, J.; Martín-Cuesta, J.; Carrasco, J.J.; Pérez-Alenda, S.; Cruz-Montecinos, C.; Andersen, L.L.; Querol-Giner, F.; Casaña, J. Safety, Fear and Neuromuscular Responses after a Resisted Knee Extension Performed to Failure in Patients with Severe Haemophilia. J. Clin. Med. 2021, 10, 2587. https://doi.org/10.3390/jcm10122587

AMA Style

Calatayud J, Martín-Cuesta J, Carrasco JJ, Pérez-Alenda S, Cruz-Montecinos C, Andersen LL, Querol-Giner F, Casaña J. Safety, Fear and Neuromuscular Responses after a Resisted Knee Extension Performed to Failure in Patients with Severe Haemophilia. Journal of Clinical Medicine. 2021; 10(12):2587. https://doi.org/10.3390/jcm10122587

Chicago/Turabian Style

Calatayud, Joaquín, Jonathan Martín-Cuesta, Juan J. Carrasco, Sofía Pérez-Alenda, Carlos Cruz-Montecinos, Lars L. Andersen, Felipe Querol-Giner, and José Casaña. 2021. "Safety, Fear and Neuromuscular Responses after a Resisted Knee Extension Performed to Failure in Patients with Severe Haemophilia" Journal of Clinical Medicine 10, no. 12: 2587. https://doi.org/10.3390/jcm10122587

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