Brief Report: Using the Internet to Identify Persons with Cognitive Impairment for Participation in Clinical Trials
Howard Chertkow
Round 1
Reviewer 1 Report
Very unusually, I have no criticisms to give of this paper. It is novel, interesting, important, and relevant. I think it should be published as is.
Reviewer 2 Report
The authors confirm in this report the feasibility of using DRA (Dementia Risk Assessment) for the identification of persons with cognitive impairments. Internet-based tests are emerging as powerfull and time-saving instruments for the selection of clinical trials participants. The results of this study, that involved more than 9000 persons over a period of 22 months, are presented in a clear and efficient way. Main rules applied in results interpretetion are described, such as exclusion criteria. Limitations of DRA-based recruitment are discussed, which adds to the value of the report. A critic analysis of DRA might guide in a correct use of these computer-based tools. Summarizing, I recommend this article for publication. The report confirms the utility of DRA and interestingly discusses its limitations. A follow-up of the study and possible recruitment of persons in clinical trials, if possible, are encouraged.
