Functional Neural Changes after Low-Frequency Bilateral Globus Pallidus Internus Deep Brain Stimulation for Post-Hypoxic Cortical Myoclonus: Voxel-Based Subtraction Analysis of Serial Positron Emission
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Data
2.2. Surgical Procedures
2.3. Brain Image Acquisition and Preprocessing
2.4. Voxel-Based Subtraction Analysis of PET
3. Results
3.1. Clinical Course
3.2. Voxel-Based Subtraction Analysis of PET
4. Discussion
4.1. Bilateral Gpi Deep Brain Stimulation for Post-Hypoxic Myoclonus
4.2. Pathophysiology of Post-Hypoxic Myoclonus
4.3. Gpi DBS Reduced Glucose Metabolism in Prefrontal Cortex
4.4. Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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SISCOM 1 Year After Deep Brain Stimulation | |||
---|---|---|---|
Anatomical Region | MNI Coordinates | Number of Voxels | Maximum Subtraction Value (%) |
L Putamen | −28, −12, −2 | 167 | 19.38 |
R Putamen | 28, −4, −2 | 60 | 16.62 |
L Pallidum | −26, −6, −4 | 110 | 20.77 |
R Pallidum | 26, −8, −4 | 133 | 20.77 |
L Thalamus | −14, −12, −2 | 33 | 22.15 |
R Thalamus | 14, −10, −2 | 6 | 16.62 |
L Middle Frontal Gyrus | −36, 12, 44 | 698 | −48.46 |
R Middle Frontal Gyrus | 32, 26, 52 | 259 | −23.54 |
L Precentral Gyrus | −40, −2, 56 | 267 | 22.15 |
R Precentral Gyrus | 24, −14, 56 | 7 | 16.62 |
L Midbrain | −14, −14, −8 | 98 | 30.46 |
R Midbrain | 14, −10, −2 | 47 | 16.62 |
L Inferior Temporal Gyrus | −38, −6, −46 | 95 | 20.77 |
R Interior Temporal Gyrus | 44, 4, −46 | 149 | 24.92 |
SISCOM 3 Years After Deep Brain Stimulation | |||
---|---|---|---|
Anatomical Region | MNI Coordinates | Number of Voxels | Maximum Subtraction Value (%) |
L InferiorTemporal Gyrus | −32, −8, −44 | 44 | −42.92 |
R InteriorTemporal Gyrus | 38, −4, −46 | 61 | −34.61 |
L InferiorFronto-Orbital Gyrus | −34, 46, −16 | 95 | −34.61 |
R InferiorFronto-Orbital Gyrus | 48, 46, −4 | 132 | −45.69 |
R Supramarginal Gyrus | 58, −32, 44 | 180 | −41.54 |
L Supramarginal Gyrus | −60, −28, 38 | 89 | −41.54 |
R Postcentral Gyrus | 50, −32, 50 | 17 | −34.61 |
L Postcental Gyrus | −62, −20, 30 | 4 | −30.46 |
R Cuneus | 8, −94, 24 | 46 | 40.15 |
L Cuneus | −4, −94, 20 | 106 | 38.77 |
R Calcarine Sulcus | 4, −70, 8 | 55 | 30.46 |
L Calcarine Sulcus | −2, −76, 6 | 119 | 34.61 |
R Insular | 30, 28, 6 | 4 | 27.69 |
L Insular | −30, 28, 12 | 161 | 41.54 |
R Anterior Cingulate Cortex | 2, 28, 0 | 4 | 33.23 |
L Anterior Cingulate Cortex | −8, 28, −4 | 41 | 48.46 |
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Kim, M.J.; Park, S.H.; Heo, K.; Chang, J.W.; Kim, J.I.; Chang, W.S. Functional Neural Changes after Low-Frequency Bilateral Globus Pallidus Internus Deep Brain Stimulation for Post-Hypoxic Cortical Myoclonus: Voxel-Based Subtraction Analysis of Serial Positron Emission. Brain Sci. 2020, 10, 730. https://doi.org/10.3390/brainsci10100730
Kim MJ, Park SH, Heo K, Chang JW, Kim JI, Chang WS. Functional Neural Changes after Low-Frequency Bilateral Globus Pallidus Internus Deep Brain Stimulation for Post-Hypoxic Cortical Myoclonus: Voxel-Based Subtraction Analysis of Serial Positron Emission. Brain Sciences. 2020; 10(10):730. https://doi.org/10.3390/brainsci10100730
Chicago/Turabian StyleKim, Myung Ji, So Hee Park, Kyoung Heo, Jin Woo Chang, Joong Il Kim, and Won Seok Chang. 2020. "Functional Neural Changes after Low-Frequency Bilateral Globus Pallidus Internus Deep Brain Stimulation for Post-Hypoxic Cortical Myoclonus: Voxel-Based Subtraction Analysis of Serial Positron Emission" Brain Sciences 10, no. 10: 730. https://doi.org/10.3390/brainsci10100730