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Volume 12
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10.3390/app12073621
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Article

Preparation of Nanoparticle-Loaded Microbubbles via an Electrohydrodynamic Atomization Process

by
Xin-Bin Nie
1,
Yong Wang
1,
Xiong Ran
1,
Ji-Chuan Wu
2,*,
Ran Wei
1,* and
Wei-Cheng Yan
1,*
1
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China
2
Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang 621900, China
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2022, 12(7), 3621; https://doi.org/10.3390/app12073621
Submission received: 11 March 2022 / Revised: 28 March 2022 / Accepted: 31 March 2022 / Published: 2 April 2022
(This article belongs to the Special Issue Synthesis and Application of Microcapsules)
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Abstract

Microbubbles have been widely used in many research fields due to their outstanding physicochemical properties and unique structural characteristics, especially as ultrasonic contrast agents and drug delivery carriers. However, the stability of conventional microbubbles is generally poor, which limits the development of their applications. Loading nanoparticle to microbubbles has great potential in enhancing the stability of microbubbles. This paper reports for the first time the feasibility of one-step preparation of nanoparticle-loaded microbubbles by coaxial electrohydrodynamic atomization. Bovine serum albumin (BSA) was used as the model material of the bubble shell layer to study the effect of the loading of nanoparticles on the stability of microbubbles. The results show that the concentration of nanoparticles has a significant impact on the stability of microbubbles, and loading an appropriate amount of nanoparticles is helpful in improving the stability of microbubbles. The results also show that nanoparticle-loaded microbubbles with a size distribution in the range of 120–200 μm can be prepared under optimal conditions.
Keywords: microbubbles; electrohydrodynamic; coaxial spraying; nanoparticle loading; stability microbubbles; electrohydrodynamic; coaxial spraying; nanoparticle loading; stability

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MDPI and ACS Style

Nie, X.-B.; Wang, Y.; Ran, X.; Wu, J.-C.; Wei, R.; Yan, W.-C. Preparation of Nanoparticle-Loaded Microbubbles via an Electrohydrodynamic Atomization Process. Appl. Sci. 2022, 12, 3621. https://doi.org/10.3390/app12073621

AMA Style

Nie X-B, Wang Y, Ran X, Wu J-C, Wei R, Yan W-C. Preparation of Nanoparticle-Loaded Microbubbles via an Electrohydrodynamic Atomization Process. Applied Sciences. 2022; 12(7):3621. https://doi.org/10.3390/app12073621

Chicago/Turabian Style

Nie, Xin-Bin, Yong Wang, Xiong Ran, Ji-Chuan Wu, Ran Wei, and Wei-Cheng Yan. 2022. "Preparation of Nanoparticle-Loaded Microbubbles via an Electrohydrodynamic Atomization Process" Applied Sciences 12, no. 7: 3621. https://doi.org/10.3390/app12073621

APA Style

Nie, X.-B., Wang, Y., Ran, X., Wu, J.-C., Wei, R., & Yan, W.-C. (2022). Preparation of Nanoparticle-Loaded Microbubbles via an Electrohydrodynamic Atomization Process. Applied Sciences, 12(7), 3621. https://doi.org/10.3390/app12073621

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