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Medical Sciences, Volume 8, Issue 4

2020 December - 11 articles

Cover Story: Extracellular vesicles (EVs) are lipid-bound nanoparticles generated by most cell types and can be isolated from many biological fluids. EVs are known to play a critical role in intercellular communication and inter-organ crosstalk through the delivery of their EV cargo, which is made up of a broad spectrum of molecules, including lipids, proteins, and nucleic acids. The composition of EV cargo is dependent on both the cell type and current pathophysiological status of the host cell. Although the mechanisms behind the production, secretion, and selective packaging of cargo in EVs remain somewhat misunderstood, recent evidence suggests that caveolin-1 regulates these processes in some EVs. In this article, we review the current understanding of this emerging and novel role of caveolin-1. View this paper.
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Articles (11)

  • Review
  • Open Access
32 Citations
7,095 Views
27 Pages

Barocrinology: The Endocrinology of Obesity from Bench to Bedside

  • Sanjay Kalra,
  • Nitin Kapoor,
  • Saptarshi Bhattacharya,
  • Hassan Aydin and
  • Ankia Coetzee

21 December 2020

Obesity has reached pandemic proportions. Hormonal and metabolic imbalances are the key factors that lead to obesity. South Asian populations have a unique phenotype, peculiar dietary practices, and a high prevalence of consanguinity. Moreover, many...

  • Feature Paper
  • Article
  • Open Access
2 Citations
2,932 Views
10 Pages

Association of Low Serum 25OHD Levels with Abnormal Bone Microarchitecture in Well-Differentiated Thyroid Cancer

  • Federico Hawkins Carranza,
  • Sonsoles Guadalix Iglesias,
  • María Luisa De Mingo Dominguez,
  • Gonzalo Allo Miguel,
  • Cristina Martín-Arriscado Arroba,
  • Begoña López Alvares and
  • Guillermo Martínez Diaz-Guerra

1 December 2020

The association of low levels of 25 hydroxyvitamin D (25OHD) with papillary thyroid cancer (PTC) is being studied, as to whether it is a risk factor or as a coincidental one. This study aimed to evaluate serum levels of deficiency, insufficiency, and...

  • Article
  • Open Access
6 Citations
4,665 Views
9 Pages

Reliability of the Soleus H-Reflex in Different Sitting Postures

  • Hamad S. Al Amer,
  • Mohamed A. Sabbahi and
  • Sharon L. Olson

25 November 2020

The Soleus (SOL) Hoffmann reflex (H-reflex) is commonly recorded in sitting position. However, the reliability of recording is unknown. We assessed the reliability of SOL H-reflex amplitude measurements across multiple traces and sessions during erec...

  • Article
  • Open Access
55 Citations
6,368 Views
16 Pages

Efficacy and Safety of SGLT-2 Inhibitors for Treatment of Diabetes Mellitus among Kidney Transplant Patients: A Systematic Review and Meta-Analysis

  • Api Chewcharat,
  • Narut Prasitlumkum,
  • Charat Thongprayoon,
  • Tarun Bathini,
  • Juan Medaura,
  • Saraschandra Vallabhajosyula and
  • Wisit Cheungpasitporn

17 November 2020

Background: The objective of this systematic review was to evaluate the efficacy and safety profiles of sodium-glucose co-transporter 2 (SGLT-2) inhibitors for treatment of diabetes mellitus (DM) among kidney transplant patients. Methods: We conducte...

  • Review
  • Open Access
42 Citations
6,225 Views
13 Pages

The Evolving Role of Caveolin-1: A Critical Regulator of Extracellular Vesicles

  • Kareemah Ni,
  • Chenghao Wang,
  • Jonathan M Carnino and
  • Yang Jin

4 November 2020

Emerging evidence suggests that extracellular vesicles (EVs) play an essential role in mediating intercellular communication and inter-organ crosstalk both at normal physiological conditions and in the pathogenesis of human diseases. EV cargos are ma...

  • Communication
  • Open Access
6 Citations
3,665 Views
9 Pages

30 October 2020

This study aimed to determine the various demographic and work-related professional characteristics associated with low back pain among nursing professionals in Najran, Saudi Arabia. A self-administered modified questionnaire (electronic), which incl...

  • Article
  • Open Access
41 Citations
6,268 Views
15 Pages

Treatment of C3 Glomerulopathy in Adult Kidney Transplant Recipients: A Systematic Review

  • Maria L Gonzalez Suarez,
  • Charat Thongprayoon,
  • Panupong Hansrivijit,
  • Karthik Kovvuru,
  • Swetha R Kanduri,
  • Narothama R Aeddula,
  • Aleksandra I Pivovarova,
  • Api Chewcharat,
  • Tarun Bathini and
  • Wisit Cheungpasitporn
  • + 2 authors

21 October 2020

Background: C3 glomerulopathy (C3G), a rare glomerular disease mediated by alternative complement pathway dysregulation, is associated with a high rate of recurrence and graft loss after kidney transplantation (KTx). We aimed to assess the efficacy o...

  • Article
  • Open Access
5 Citations
3,143 Views
11 Pages

9 October 2020

Inflammation is a common adverse event of anti-cancer therapy. Royal jelly (RJ) modulates inflammation by regulating the levels of tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β, and interleukin (IL)-6 produced by macrop...

  • Article
  • Open Access
5 Citations
3,277 Views
10 Pages

Artificial Neural Network as a Tool to Predict Facial Nerve Palsy in Parotid Gland Surgery for Benign Tumors

  • Carlos M Chiesa-Estomba,
  • Jon A Sistiaga-Suarez,
  • José Ángel González-García,
  • Ekhiñe Larruscain,
  • Giovanni Cammaroto,
  • Miguel Mayo-Yánez,
  • Jerome R Lechien,
  • Christian Calvo-Henríquez,
  • Xabier Altuna and
  • Alfonso Medela

7 October 2020

(1) Background: Despite the increasing use of intraoperative facial nerve monitoring during parotid gland surgery or the improvement in the preoperative radiological assessment, facial nerve injury (FNI) continues to be the most feared complication;...

  • Article
  • Open Access
3 Citations
3,601 Views
13 Pages

Treatment of Swine Closed Head Injury with Perfluorocarbon NVX-428

  • Francoise Arnaud,
  • Ashraful Haque,
  • MAJ Erin Morris,
  • Paula Moon-Massat,
  • Charles Auker,
  • Saha Biswajit,
  • Brittany Hazzard,
  • Lam Thuy Vi Tran Ho,
  • Richard McCarron and
  • Anke Scultetus

27 September 2020

Pre-hospital treatment of traumatic brain injury (TBI) with co-existing polytrauma is complicated by requirements for intravenous fluid volume vs. hypotensive resuscitation. A low volume, small particle-size-oxygen-carrier perfluorocarbon emulsion NV...

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Med. Sci. - ISSN 2076-3271