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Genetic Diversity among Pseudorabies Viruses Isolated from Dogs in France from 2006 to 2018

ANSES, Ploufragan-Plouzané-Niort Laboratory, Swine Virology Immunology Unit, National Reference Laboratory and OIE Reference Laboratory for Aujeszky’s Disease, 22440 Ploufragan, France
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Pathogens 2019, 8(4), 266; https://doi.org/10.3390/pathogens8040266
Received: 6 November 2019 / Revised: 22 November 2019 / Accepted: 23 November 2019 / Published: 26 November 2019
(This article belongs to the Special Issue Pseudorabies Virus Infections)
Pseudorabies (PR), also known as Aujeszky’s disease, is an economically important disease for the pig industry. It has been eradicated in domestic pigs in many European countries, including France, but its causative agent—Suid Herpesvirus 1—is still circulating in wild boars. The risk of endemic PR in wild fauna lies in reintroducing the virus among domestic pigs and transmitting it to other mammals, especially hunting dogs for which the disease is rapidly fatal. As such infections are regularly reported in France, this study genetically characterized canine PR virus strains in the country to obtain information on their diversity and evolution. Partial sequencing of the glycoprotein C-encoding gene from 55 virus strains isolated from dogs between 2006 and 2018 showed that 14 strains belonged to genotype I-clade A and another 38 to genotype I-clade B, two clades usually reported in Western Europe. More surprisingly, three strains were found to belong to genotype II, suggesting an Asian origin. Genotype I-clade A strains exhibited the highest diversity as five geographically segregated genogroups were identified. View Full-Text
Keywords: pseudorabies; Aujeszky’s disease; phylogenetic analysis; gC encoding region; hunting dog; wild boar pseudorabies; Aujeszky’s disease; phylogenetic analysis; gC encoding region; hunting dog; wild boar
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Deblanc, C.; Oger, A.; Simon, G.; Le Potier, M.-F. Genetic Diversity among Pseudorabies Viruses Isolated from Dogs in France from 2006 to 2018. Pathogens 2019, 8, 266.

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