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Antiviral Activity of Germacrone against Pseudorabies Virus in Vitro

Joint International Research Laboratory of Animal Health and Food Safety, Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210000, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Pathogens 2019, 8(4), 258;
Received: 24 September 2019 / Revised: 18 November 2019 / Accepted: 19 November 2019 / Published: 22 November 2019
(This article belongs to the Special Issue Pseudorabies Virus Infections)
Pseudorabies virus (PRV), a member of the Herpesviridae, is the causative agent of an acute infectious disease in a variety of animals. The emergence of a novel variant strain brought huge economic losses to the pig industry since classical vaccine strains were not completely effective against variant strains. Therefore, the development of new anti-pseudorabies virus drugs and vaccines is of great significance for the treatment and prevention of pseudorabies. In this study, we found that germacrone, one of the major components of the essential oils extracted from Rhizoma Curcuma, was able to effectively inhibit PRV replication in a dose-dependent manner in vitro. Germacrone showed antiviral activity against PRV in the early phase of the viral replication cycle. Moreover, we found that germacrone does not directly kill the virus, nor does it affect the expression of the PRV receptor protein nectin-1, nectin-2, and CD155. Our results suggest germacrone could be used as an efficient microbicide or immunomodulatory agent in the control of the emerging variant PRV. View Full-Text
Keywords: PRV; germacrone; antiviral PRV; germacrone; antiviral
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MDPI and ACS Style

He, W.; Zhai, X.; Su, J.; Ye, R.; Zheng, Y.; Su, S. Antiviral Activity of Germacrone against Pseudorabies Virus in Vitro. Pathogens 2019, 8, 258.

AMA Style

He W, Zhai X, Su J, Ye R, Zheng Y, Su S. Antiviral Activity of Germacrone against Pseudorabies Virus in Vitro. Pathogens. 2019; 8(4):258.

Chicago/Turabian Style

He, Wanting, Xiaofeng Zhai, Jingyin Su, Rui Ye, Yuna Zheng, and Shuo Su. 2019. "Antiviral Activity of Germacrone against Pseudorabies Virus in Vitro" Pathogens 8, no. 4: 258.

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