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Open AccessReview

Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion

1
Department of Medicine, Addenbrooke’s Hospital, University of Cambridge, Cambs CB2 0QQ UK
2
Parasites and Microbes, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambs CB10 1SA, UK
Pathogens 2019, 8(4), 186; https://doi.org/10.3390/pathogens8040186
Received: 19 September 2019 / Revised: 10 October 2019 / Accepted: 11 October 2019 / Published: 12 October 2019
(This article belongs to the Special Issue Human Herpesviruses: Diversity and Disease)
The nine human herpesviruses are some of the most ubiquitous pathogens worldwide, causing life-long latent infection in a variety of different tissues. Human herpesviruses range from mild childhood infections to known tumour viruses and ‘trolls of transplantation’. Epstein-Barr virus was the first human herpesvirus to have its whole genome sequenced; GenBank now includes thousands of herpesvirus genomes. This review will cover some of the recent advances in our understanding of herpesvirus diversity and disease that have come about as a result of new sequencing technologies, such as target enrichment and long-read sequencing. It will also look at the problem of resolving mixed-genotype infections, whether with short or long-read sequencing methods; and conclude with some thoughts on the future of the field as herpesvirus population genomics becomes a reality. View Full-Text
Keywords: genomics; herpesviruses; DNA viruses; population genetics; clinical sequencing genomics; herpesviruses; DNA viruses; population genetics; clinical sequencing
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Houldcroft, C.J. Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion. Pathogens 2019, 8, 186.

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