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Article

Genomic Epidemiology of Streptococcus suis Sequence Type 7 Sporadic Infections in the Guangxi Zhuang Autonomous Region of China

by
Mingliu Wang
1,†,
Pengcheng Du
2,†,
Jianping Wang
3,†,
Ruiting Lan
4,
Jun Huang
1,
Ming Luo
5,
Yan Jiang
6,
Jun Zeng
1,
Yi Quan
1,
Zhaohui Shi
7 and
Han Zheng
3,*
1
Guangxi Zhuang Autonomous Region Center for Disease Prevention and Control, Nanning 530028, China
2
Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
3
State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing 102206, China
4
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
5
Yulin Center for Disease Prevention and Control, Yulin 537000, China
6
Qinzhou Center for Disease Prevention and Control, Qinzhou 535099, China
7
Guilin Center for Disease Prevention and Control, Guilin 541001, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to the study.
Pathogens 2019, 8(4), 187; https://doi.org/10.3390/pathogens8040187
Submission received: 2 September 2019 / Revised: 8 October 2019 / Accepted: 8 October 2019 / Published: 12 October 2019
(This article belongs to the Special Issue Update on Streptococcus suis Research and Prevention in the Era of Antibiotic Restriction - 4th International Workshop on Streptococcus suis)
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Abstract

Streptococcus suis is an important zoonotic pathogen. Serotype 2 and sequence type (ST) 1 are the most frequently reported strains in both infected humans and pigs. ST7 is only endemic to China, and it was responsible for outbreaks in 1998 and 2005 in China. In the present study, 38 sporadic ST7 S. suis strains, which mostly caused sepsis, were collected from patients in the Guangxi Zhuang Autonomous Region (GX) between 2007 and 2018. Of 38 sporadic ST7 strains, serotype 14 was the most frequent (27 strains, 71.1%), followed by serotype 2 (11 strains, 28.9%). The phylogenetic structure of the ST7 population, including epidemic and sporadic ST7 strains, was constructed using mutational single-nucleotide polymorphisms (SNPs). High diversity within the ST7 population was revealed and divided into five lineages. Only one sporadic ST7 strain, GX14, from a Streptococcal toxic-shock-like syndrome (STSLS) patient was clustered into the same lineage as the epidemic strains. GX14 and the epidemic strains diverged in 1974. The sporadic ST7 strains of GX were mainly clustered into lineage 5, which emerged in 1980. Comparing to genome of epidemic strain, the major differences in genome of sporadic ST7 strains of GX was the absence of 89 kb pathogenicity island (PAI) specific to epidemic strain and insertion of 128 kb ICE_phage tandem MGE or ICE portion of the MGE. These mobile elements play a significant role in the horizontal transfer of antibiotic resistance genes in sporadic ST7 strains. Our results enhanced the understanding of the evolution of the ST7 strains and their ability to cause life-threatening infections in humans.
Keywords: Streptococcus suis; sequence type 7; sporadic strain; serotype 14; phylogenetic structure; comparative genomes Streptococcus suis; sequence type 7; sporadic strain; serotype 14; phylogenetic structure; comparative genomes

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MDPI and ACS Style

Wang, M.; Du, P.; Wang, J.; Lan, R.; Huang, J.; Luo, M.; Jiang, Y.; Zeng, J.; Quan, Y.; Shi, Z.; et al. Genomic Epidemiology of Streptococcus suis Sequence Type 7 Sporadic Infections in the Guangxi Zhuang Autonomous Region of China. Pathogens 2019, 8, 187. https://doi.org/10.3390/pathogens8040187

AMA Style

Wang M, Du P, Wang J, Lan R, Huang J, Luo M, Jiang Y, Zeng J, Quan Y, Shi Z, et al. Genomic Epidemiology of Streptococcus suis Sequence Type 7 Sporadic Infections in the Guangxi Zhuang Autonomous Region of China. Pathogens. 2019; 8(4):187. https://doi.org/10.3390/pathogens8040187

Chicago/Turabian Style

Wang, Mingliu, Pengcheng Du, Jianping Wang, Ruiting Lan, Jun Huang, Ming Luo, Yan Jiang, Jun Zeng, Yi Quan, Zhaohui Shi, and et al. 2019. "Genomic Epidemiology of Streptococcus suis Sequence Type 7 Sporadic Infections in the Guangxi Zhuang Autonomous Region of China" Pathogens 8, no. 4: 187. https://doi.org/10.3390/pathogens8040187

APA Style

Wang, M., Du, P., Wang, J., Lan, R., Huang, J., Luo, M., Jiang, Y., Zeng, J., Quan, Y., Shi, Z., & Zheng, H. (2019). Genomic Epidemiology of Streptococcus suis Sequence Type 7 Sporadic Infections in the Guangxi Zhuang Autonomous Region of China. Pathogens, 8(4), 187. https://doi.org/10.3390/pathogens8040187

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