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Molecular Responses to the Zika Virus in Mosquitoes

Max Planck Tandem Group in Mosquito Reproductive Biology, University of Antioquia, Calle 67 #53-108, Medellín 050010, Colombia
Instituto Colombiano de Medicina Tropical, Carerra 43A # 52 sur-99, Sabaneta 055450, Colombia
Author to whom correspondence should be addressed.
Pathogens 2018, 7(2), 49;
Received: 24 March 2018 / Revised: 23 April 2018 / Accepted: 28 April 2018 / Published: 3 May 2018
(This article belongs to the Special Issue Virus-Host Interactions of Zika Virus)
PDF [240 KB, uploaded 3 May 2018]


The Zika virus (ZIKV), originally discovered in 1947, did not become a major concern until the virus swept across the Pacific and into the Americas in the last decade, bringing with it news of neurological complications and birth defects in ZIKV affected areas. This prompted researchers to dissect the molecular interactions between ZIKV and the mosquito vector in an attempt to better understand not only the changes that occur upon infection, but to also identify molecules that may potentially enhance or suppress a mosquito’s ability to become infected and/or transmit the virus. Here, we review what is currently known regarding ZIKV-mosquito molecular interactions, focusing on ZIKV infection of Aedes aegypti and Aedes albopictus, the primary species implicated in transmitting ZIKV during the recent outbreaks. View Full-Text
Keywords: Flavivirus; ZIKV; Aedes aegypti; Aedes albopictus Flavivirus; ZIKV; Aedes aegypti; Aedes albopictus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Alfonso-Parra, C.; Avila, F.W. Molecular Responses to the Zika Virus in Mosquitoes. Pathogens 2018, 7, 49.

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