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Pathogens 2018, 7(2), 51;

Zika Virus Trafficking and Interactions in the Human Male Reproductive Tract

Departamento de Ciências da Saúde, Universidade Salgado de Oliveira, Juiz de Fora, Minas Gerais, CEP 36036-000, Brazil
Received: 21 March 2018 / Revised: 1 May 2018 / Accepted: 2 May 2018 / Published: 11 May 2018
(This article belongs to the Special Issue Virus-Host Interactions of Zika Virus)
PDF [776 KB, uploaded 11 May 2018]


Sexual transmission of Zika virus (ZIKV) is a matter of great concern. Infectious viral particles can be shed in semen for as long as six months after infection and can be transferred to male and female sexual partners during unprotected sexual intercourse. The virus can be found inside spermatozoa and could be directly transferred to the oocyte during fertilization. Sexual transmission of ZIKV can contribute to the rise in number of infected individuals in endemic areas as well as in countries where the mosquito vector does not thrive. There is also the possibility, as has been demonstrated in mouse models, that the vaginal deposition of ZIKV particles present in semen could lead to congenital syndrome. In this paper, we review the current literature to understand ZIKV trafficking from the bloodstream to the human male reproductive tract and viral interactions with host cells in interstitial spaces, tubule walls, annexed glands and semen. We hope to highlight gaps to be filled by future research and potential routes for vaccine and antiviral development. View Full-Text
Keywords: Zika virus; sexual transmission; male reproductive tract; human reproduction Zika virus; sexual transmission; male reproductive tract; human reproduction

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Da Silva, L.R.C. Zika Virus Trafficking and Interactions in the Human Male Reproductive Tract. Pathogens 2018, 7, 51.

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