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J. Pers. Med. 2018, 8(4), 40; https://doi.org/10.3390/jpm8040040

ATP-Binding Cassette Transporters in the Clinical Implementation of Pharmacogenetics

1
Pharmacy Department, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio, 28007 Madrid, Spain
2
Spanish Clinical Research Network (SCReN), 28040 Madrid, Spain
Received: 31 August 2018 / Revised: 3 December 2018 / Accepted: 3 December 2018 / Published: 5 December 2018
(This article belongs to the Special Issue Personalized Medicine Based on Drug Transporter Genetic Heterogeneity)
Full-Text   |   PDF [298 KB, uploaded 20 December 2018]

Abstract

ATP-binding cassette (ABC) transporters are involved in a large number of processes and contribute to various human genetic diseases. Among other functions, ABC proteins are involved in the transport of multiple drugs through cells. Most of the genes coding for these transporters are highly polymorphic and DNA variants in these genes can affect the normal functioning of these proteins, affecting the way drugs are transported, increasing or decreasing drug levels. These changes in the intracellular and extracellular drug levels may be associated with altered drug effectiveness or severe drug-induced adverse events. This review presents a state-of-art of the most pharmacogenetics clinically relevant ABC transporters closed to the clinical implementation. View Full-Text
Keywords: pharmacogenomics; ATP-binding cassette; adverse drug reactions; drug efficacy pharmacogenomics; ATP-binding cassette; adverse drug reactions; drug efficacy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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López-Fernández, L.A. ATP-Binding Cassette Transporters in the Clinical Implementation of Pharmacogenetics. J. Pers. Med. 2018, 8, 40.

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