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Review

The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders

by 1,*, 2,3, 4 and 1,5
1
School of Medicine Greenville, University of South Carolina, Greenville, SC 29615, USA
2
Laboratory of Psychopathology and Health Processes, University of Paris, 92100 Boulogne Billancourt, France
3
Department of Emergency Psychiatry and Acute Care, CHU Montpellier, 34000 Montpellier, France
4
Greenwood Genetic Center, Greenville, SC 29605, USA
5
Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2020, 10(4), 260; https://doi.org/10.3390/jpm10040260
Received: 12 November 2020 / Revised: 29 November 2020 / Accepted: 29 November 2020 / Published: 1 December 2020
Considerable interest has arisen concerning the relationship between hereditary connective tissue disorders such as the Ehlers-Danlos syndromes (EDS)/hypermobility spectrum disorders (HSD) and autism, both in terms of their comorbidity as well as co-occurrence within the same families. This paper reviews our current state of knowledge, as well as highlighting unanswered questions concerning this remarkable patient group, which we hope will attract further scientific interest in coming years. In particular, patients themselves are demanding more research into this growing area of interest, although science has been slow to answer that call. Here, we address the overlap between these two spectrum conditions, including neurobehavioral, psychiatric, and neurological commonalities, shared peripheral neuropathies and neuropathologies, and similar autonomic and immune dysregulation. Together, these data highlight the potential relatedness of these two conditions and suggest that EDS/HSD may represent a subtype of autism. View Full-Text
Keywords: autism spectrum disorder; Ehlers-Danlos syndrome; hypermobility spectrum disorders; autonomic disorder; mast cell activation syndrome autism spectrum disorder; Ehlers-Danlos syndrome; hypermobility spectrum disorders; autonomic disorder; mast cell activation syndrome
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MDPI and ACS Style

Casanova, E.L.; Baeza-Velasco, C.; Buchanan, C.B.; Casanova, M.F. The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders. J. Pers. Med. 2020, 10, 260. https://doi.org/10.3390/jpm10040260

AMA Style

Casanova EL, Baeza-Velasco C, Buchanan CB, Casanova MF. The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders. Journal of Personalized Medicine. 2020; 10(4):260. https://doi.org/10.3390/jpm10040260

Chicago/Turabian Style

Casanova, Emily L., Carolina Baeza-Velasco, Caroline B. Buchanan, and Manuel F. Casanova. 2020. "The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders" Journal of Personalized Medicine 10, no. 4: 260. https://doi.org/10.3390/jpm10040260

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