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Open AccessArticle

Measurement of Oral Epithelial Thickness by Optical Coherence Tomography

Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania—Luigi Vanvitelli, 80138 Naples, Italy
Department of Medicine and Surgery, Centre of Neuroscience of Milan, University of Milano-Bicocca, 20126 Milan, Italy
ECU School of Dental Medicine, 1851 MacGregor Downs Road, Greenville, NC 27834, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Diagnostics 2019, 9(3), 90;
Received: 2 July 2019 / Revised: 19 July 2019 / Accepted: 5 August 2019 / Published: 6 August 2019
(This article belongs to the Special Issue Ultrasound Imaging in Medicine 2019)
Optical coherence tomography (OCT) is a real-time, in-situ, non-invasive imaging device that is able to perform a cross-sectional evaluation of tissue microstructure based on the specific intensity of back-scattered and reflected light. The aim of the present study was to define normal values of epithelial thickness within the oral cavity. OCT measurements of epithelial thickness were performed in 28 healthy patients at six different locations within the oral cavity. Image analysis was performed using Image J 1.52 software. The healthy epithelium has a mean thickness of 335.59 ± 150.73 µm. According to its location within the oral cavity, the epithelium showed highest values in the region of the buccal mucosa (659.79 µm) and the thinnest one was observed in the mouth’s floor (100.07 µm). OCT has been shown to be useful for the evaluation of oral mucosa in vivo and in real time. Our study provides reference values for the epithelial thickness of multiple sites within the oral cavity. Knowledge of the thickness values of healthy mucosa is, therefore, of fundamental importance. View Full-Text
Keywords: in vivo; oral mucosa; optical coherence tomography in vivo; oral mucosa; optical coherence tomography
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Di Stasio, D.; Lauritano, D.; Iquebal, H.; Romano, A.; Gentile, E.; Lucchese, A. Measurement of Oral Epithelial Thickness by Optical Coherence Tomography. Diagnostics 2019, 9, 90.

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