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Article

Intraosteal Behavior of Porous Scaffolds: The mCT Raw-Data Analysis as a Tool for Better Understanding

1
Image Diagnostic Service, Virgen de la Arrixaca University Hospital, El Palmar, 30120 Murcia, Spain
2
Faculty of Medicine, Universidad de Murcia, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), 30.100 Murcia, Spain
3
Department of Orthopaedic Surgery and Trauma, School of Medicine, Lab of Regeneration and Tissue Repair, UCAM-Universidad Catolica San Antonio de Murcia, Guadalupe, 30107 Murcia, Spain
4
Pathology Unit, Biomedical Research Institute of Murcia (IMIB-Arrixaca-UMU), El Palmar, 30120 Murcia, Spain
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Orthopaedic and Trauma Service, Virgen de la Arrixaca University Hospital, El Palmar, 30120 Murcia, Spain
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Department of Oral Surgery and Implant Dentistry, Faculty of Health Sciences, UCAM- Universidad Católica San Antonio de Murcia, Guadalupe, 30107 Murcia, Spain
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Cátedra Internacional de Análisis Estadístico y Big Data, Universidad Católica de Murcia, 30107 Murcia, Spain
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Department of Dental Research in Universidad Federico Henriquez y Carvajal (UFHEC), Santo Domingo 10107, Dominican Republic
9
Department of Medicina Oral, Facultad de Medicina, Universidad de Murcia, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), 30.100 Murcia, Spain
10
Instituto de Bioingenieria, Universidad Miguel Hernandez, 03202 Elche, Spain
*
Author to whom correspondence should be addressed.
Symmetry 2019, 11(4), 532; https://doi.org/10.3390/sym11040532
Received: 10 March 2019 / Revised: 2 April 2019 / Accepted: 10 April 2019 / Published: 12 April 2019
(This article belongs to the Special Issue Dental Implant Macrogeometry and Biomaterials)
The aim of the study is to determine the existing correlation between high-resolution 3D imaging technique obtained through Micro Computed Tomography (mCT) and histological-histomorphometric images to determine in vivo bone osteogenic behavior of bioceramic scaffolds. A Ca-Si-P scaffold ceramic doped and non-doped (control) with a natural demineralized bone matrix (DBM) were implanted in rabbit tibias for 1, 3, and 5 months. A progressive disorganization and disintegration of scaffolds and bone neoformation occurs, from the periphery to the center of the implants, without any differences between histomorphometric and radiological analysis. However, significant differences (p < 0.05) between DMB-doped and non-doped materials where only detected through mathematical analysis of mCT. In this way, average attenuation coefficient for DMB-doped decreased from 0.99 ± 0.23 Hounsfield Unit (HU) (3 months) to 0.86 ± 0.32 HU (5 months). Average values for non-doped decreased from 0.86 ± 0.25 HU (3 months) to 0.66 ± 0.33 HU. Combination of radiological analysis and mathematical mCT seems to provide an adequate in vivo analysis of bone-implanted biomaterials after surgery, obtaining similar results to the one provided by histomorphometric analysis. Mathematical analysis of Computed Tomography (CT) would allow the conducting of long-term duration in vivo studies, without the need for animal sacrifice, and the subsequent reduction in variability. View Full-Text
Keywords: ceramic scaffolds; demineralized bone matrix; bone regeneration; micro-CT; histomorphometry ceramic scaffolds; demineralized bone matrix; bone regeneration; micro-CT; histomorphometry
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MDPI and ACS Style

Parrilla-Almansa, A.; González-Bermúdez, C.A.; Sánchez-Sánchez, S.; Meseguer-Olmo, L.; Martínez-Cáceres, C.M.; Martínez-Martínez, F.; Calvo-Guirado, J.L.; Piñero de Armas, J.J.; Aragoneses, J.M.; García-Carrillo, N.; De Aza, P.N. Intraosteal Behavior of Porous Scaffolds: The mCT Raw-Data Analysis as a Tool for Better Understanding. Symmetry 2019, 11, 532. https://doi.org/10.3390/sym11040532

AMA Style

Parrilla-Almansa A, González-Bermúdez CA, Sánchez-Sánchez S, Meseguer-Olmo L, Martínez-Cáceres CM, Martínez-Martínez F, Calvo-Guirado JL, Piñero de Armas JJ, Aragoneses JM, García-Carrillo N, De Aza PN. Intraosteal Behavior of Porous Scaffolds: The mCT Raw-Data Analysis as a Tool for Better Understanding. Symmetry. 2019; 11(4):532. https://doi.org/10.3390/sym11040532

Chicago/Turabian Style

Parrilla-Almansa, Andrés, Carlos A. González-Bermúdez, Silvia Sánchez-Sánchez, Luis Meseguer-Olmo, Carlos M. Martínez-Cáceres, Francisco Martínez-Martínez, José L. Calvo-Guirado, Juan J. Piñero de Armas, Juan M. Aragoneses, Nuria García-Carrillo, and Piedad N. De Aza. 2019. "Intraosteal Behavior of Porous Scaffolds: The mCT Raw-Data Analysis as a Tool for Better Understanding" Symmetry 11, no. 4: 532. https://doi.org/10.3390/sym11040532

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