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Symmetry 2019, 11(1), 59; https://doi.org/10.3390/sym11010059

Vertical Bone Construction with Bone Marrow-Derived and Adipose Tissue-Derived Stem Cells

1
Faculdade São Leopoldo Mandic, Instituto de Pesquisas São Leopoldo Mandic, Campinas 13045-755, Brazil
2
Department of Oral and Implant Surgery. Faculty of Health Sciences, Universidad Católica San Antonio de Murcia (UCAM), 30002 Murcia, Spain
3
Department of Dental Research in Universidad Federico Henríquez y Carvajal (UFHEC), Santo Domingo 10107, Dominican Republic
*
Author to whom correspondence should be addressed.
Received: 4 December 2018 / Revised: 23 December 2018 / Accepted: 29 December 2018 / Published: 8 January 2019
(This article belongs to the Special Issue Dental Implant Macrogeometry and Biomaterials)
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Abstract

The purpose of this study was to conduct a histomorphometric analysis of bone marrow-derived and adipose tissue-derived stem cells, associated with a xenograft block, in vertical bone constructions in rabbit calvaria. Ten rabbits received two xenograft blocks on the calvaria, after decortication of the parietal bone. The blocks were fixed with titanium screws. The blocks were combined with the bone marrow-derived mesenchymal stem cells in the bone marrow stem cell (BMSC) group (right side of the calvaria) or with the adipose tissue-derived mesenchymal stem cells in the adipose tissue stem cell (ATSC) group (left side of the calvaria). After 8 weeks, the animals were sacrificed and their parietal bones were fixed in 10% formalin for the histomorphometric analysis. The following parameters were evaluated—newly formed bone (NFB), xenogeneic residual particles (XRP), and non-mineralized tissue (NMT). The histomorphometric analysis revealed 11.9 ± 7.5% and 7.6 ± 5.6% for NFB, 22.14 ± 8.5% and 21.6 ± 8.5% for XRP, and 65.8 ± 10.4% and 70.8 ± 7.4% for NMT in groups BMSC and ATSC, respectively, with statistically significant differences in the NFB and the NMT between the groups, but no differences in the XRP. Therefore, it can be concluded that the bone marrow-derived stem cells seem to have more potential for the bone formation than do the adipose tissue-derived stem cells when used in combination with the xenogenous blocks in the vertical bone construction. View Full-Text
Keywords: bone marrow cells; grafts; adipose tissue-derived stem cells bone marrow cells; grafts; adipose tissue-derived stem cells
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Carrera-Arrabal, T.; Calvo-Guirado, J.L.; Passador-Santos, F.; Sorgi da Costa, C.E.; Teles Costa, F.R.; Aloise, A.C.; Napimoga, M.H.; Aragoneses, J.M.; Pelegrine, A.A. Vertical Bone Construction with Bone Marrow-Derived and Adipose Tissue-Derived Stem Cells. Symmetry 2019, 11, 59.

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