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Recent Research Advances in Mitosis during Mammalian Gametogenesis

Beijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2019, 8(6), 567;
Received: 22 April 2019 / Revised: 2 June 2019 / Accepted: 6 June 2019 / Published: 10 June 2019
(This article belongs to the Special Issue Molecular Regulation of Mitosis and Its Role in Disease)
Mitosis is a highly sophisticated and well-regulated process during the development and differentiation of mammalian gametogenesis. The regulation of mitosis plays an essential role in keeping the formulation in oogenesis and gametogenesis. In the past few years, substantial research progress has been made by showing that cyclins/cyclin-dependent kinase (CDK) have roles in the regulation of meiosis. In addition, more functional signaling molecules have been discovered in mitosis. Growing evidence has also indicated that miRNAs influence cell cycling. In this review, we focus on specific genes, cyclins/Cdk, signaling pathways/molecules, and miRNAs to discuss the latest achievements in understanding their roles in mitosis during gametogenesis. Further elucidation of mitosis during gametogenesis may facilitate delineating all processes of mammalian reproduction and the development of disease treatments. View Full-Text
Keywords: mitosis; mammalian gametes; cyclins/Cdk mitosis; mammalian gametes; cyclins/Cdk
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MDPI and ACS Style

Wang, J.-H.; Li, Y.; Deng, S.-L.; Liu, Y.-X.; Lian, Z.-X.; Yu, K. Recent Research Advances in Mitosis during Mammalian Gametogenesis. Cells 2019, 8, 567.

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