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The Role of Mast Cells in Stroke

Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
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Cells 2019, 8(5), 437; https://doi.org/10.3390/cells8050437
Received: 1 April 2019 / Revised: 6 May 2019 / Accepted: 7 May 2019 / Published: 10 May 2019
(This article belongs to the Special Issue Mast Cells in Inflammation and Immunity)
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Abstract

Mast cells (MCs) are densely granulated perivascular resident cells of hematopoietic origin. Through the release of preformed mediators stored in their granules and newly synthesized molecules, they are able to initiate, modulate, and prolong the immune response upon activation. Their presence in the central nervous system (CNS) has been documented for more than a century. Over the years, MCs have been associated with various neuroinflammatory conditions of CNS, including stroke. They can exacerbate CNS damage in models of ischemic and hemorrhagic stroke by amplifying the inflammatory responses and promoting brain–blood barrier disruption, brain edema, extravasation, and hemorrhage. Here, we review the role of these peculiar cells in the pathophysiology of stroke, in both immature and adult brain. Further, we discuss the role of MCs as potential targets for the treatment of stroke and the compounds potentially active as MCs modulators. View Full-Text
Keywords: mast cells; stroke; neonatal hypoxic-ischemic brain injury; ischemic stroke; brain ischemia; intracerebral hemorrhage; subarachnoid hemorrhage; blood–brain barrier; inflammation mast cells; stroke; neonatal hypoxic-ischemic brain injury; ischemic stroke; brain ischemia; intracerebral hemorrhage; subarachnoid hemorrhage; blood–brain barrier; inflammation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Parrella, E.; Porrini, V.; Benarese, M.; Pizzi, M. The Role of Mast Cells in Stroke. Cells 2019, 8, 437.

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