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RAC1 Takes the Lead in Solid Tumors

1
Translational Oncology Laboratory, Avera Cancer Institute, Sioux Falls, SD 57105, USA
2
Departmental of Internal Medicine, SSOM, University of South Dakota, Sioux Falls, SD 57105, USA
*
Author to whom correspondence should be addressed.
Cells 2019, 8(5), 382; https://doi.org/10.3390/cells8050382
Received: 4 March 2019 / Revised: 18 April 2019 / Accepted: 24 April 2019 / Published: 26 April 2019
(This article belongs to the Special Issue Rho GTPases in Health and Disease)
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Abstract

Three GTPases, RAC, RHO, and Cdc42, play essential roles in coordinating many cellular functions during embryonic development, both in healthy cells and in disease conditions like cancers. We have presented patterns of distribution of the frequency of RAC1-alteration(s) in cancers as obtained from cBioPortal. With this background data, we have interrogated the various functions of RAC1 in tumors, including proliferation, metastasis-associated phenotypes, and drug-resistance with a special emphasis on solid tumors in adults. We have reviewed the activation and regulation of RAC1 functions on the basis of its sub-cellular localization in tumor cells. Our review focuses on the role of RAC1 in cancers and summarizes the regulatory mechanisms, inhibitory efficacy, and the anticancer potential of RAC1-PAK targeting agents. View Full-Text
Keywords: RAC1; sub-cellular signaling; solid tumors; resistance RAC1; sub-cellular signaling; solid tumors; resistance
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De, P.; Aske, J.C.; Dey, N. RAC1 Takes the Lead in Solid Tumors. Cells 2019, 8, 382.

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