Next Article in Journal
Parabolic, Flight-Induced, Acute Hypergravity and Microgravity Effects on the Beating Rate of Human Cardiomyocytes
Next Article in Special Issue
RAC1 Takes the Lead in Solid Tumors
Previous Article in Journal
Advances in Targeting the Epidermal Growth Factor Receptor Pathway by Synthetic Products and Its Regulation by Epigenetic Modulators as a Therapy for Glioblastoma
Previous Article in Special Issue
RHOG Activates RAC1 through CDC42 Leading to Tube Formation in Vascular Endothelial Cells
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessReview

p190RhoGAPs, the ARHGAP35- and ARHGAP5-Encoded Proteins, in Health and Disease

INSERM, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, F-33000 Bordeaux, France
UMR1053 Bordeaux Research in Translational Oncology, University of Bordeaux, BaRITOn, F-33000 Bordeaux, France
Equipe Labellisée Fondation pour la Recherche Médicale (FRM) 2018, F-33000 Bordeaux, France
Author to whom correspondence should be addressed.
Cells 2019, 8(4), 351;
Received: 19 March 2019 / Revised: 5 April 2019 / Accepted: 9 April 2019 / Published: 12 April 2019
(This article belongs to the Special Issue Rho GTPases in Health and Disease)
PDF [1207 KB, uploaded 25 April 2019]


Small guanosine triphosphatases (GTPases) gathered in the Rat sarcoma (Ras) superfamily represent a large family of proteins involved in several key cellular mechanisms. Within the Ras superfamily, the Ras homolog (Rho) family is specialized in the regulation of actin cytoskeleton-based mechanisms. These proteins switch between an active and an inactive state, resulting in subsequent inhibiting or activating downstream signals, leading finally to regulation of actin-based processes. The On/Off status of Rho GTPases implicates two subsets of regulators: GEFs (guanine nucleotide exchange factors), which favor the active GTP (guanosine triphosphate) status of the GTPase and GAPs (GTPase activating proteins), which inhibit the GTPase by enhancing the GTP hydrolysis. In humans, the 20 identified Rho GTPases are regulated by over 70 GAP proteins suggesting a complex, but well-defined, spatio-temporal implication of these GAPs. Among the quite large number of RhoGAPs, we focus on p190RhoGAP, which is known as the main negative regulator of RhoA, but not exclusively. Two isoforms, p190A and p190B, are encoded by ARHGAP35 and ARHGAP5 genes, respectively. We describe here the function of each of these isoforms in physiological processes and sum up findings on their role in pathological conditions such as neurological disorders and cancers. View Full-Text
Keywords: GTPases; GTPase-activating proteins; actin; RhoA; acto-myosin; cancers; neurological diseases GTPases; GTPase-activating proteins; actin; RhoA; acto-myosin; cancers; neurological diseases

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Héraud, C.; Pinault, M.; Lagrée, V.; Moreau, V. p190RhoGAPs, the ARHGAP35- and ARHGAP5-Encoded Proteins, in Health and Disease. Cells 2019, 8, 351.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top