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Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease

Centre for Immune Regulation, Department of Biosciences, University of Oslo, 0371 Oslo, Norway
Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy
Authors to whom correspondence should be addressed.
Cells 2019, 8(5), 396;
Received: 9 April 2019 / Revised: 25 April 2019 / Accepted: 26 April 2019 / Published: 29 April 2019
(This article belongs to the Special Issue Rho GTPases in Health and Disease)
PDF [1121 KB, uploaded 14 May 2019]


The small GTPases of the Rho family regulate many aspects of actin dynamics, but are functionally connected to many other cellular processes. Rac1, a member of this family, besides its known function in the regulation of actin cytoskeleton, plays a key role in the production of reactive oxygen species, in gene transcription, in DNA repair, and also has been proven to have specific roles in neurons. This review focuses on the cooperation between Rac1 and Rab proteins, analyzing how the coordination between these GTPases impact on cells and how alterations of their functions lead to disease. View Full-Text
Keywords: Rac1; Rab proteins; actin cytoskeleton; GTPase; Rho proteins Rac1; Rab proteins; actin cytoskeleton; GTPase; Rho proteins

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Margiotta, A.; Bucci, C. Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease. Cells 2019, 8, 396.

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