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Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients

1
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55 905, USA
2
Department of Hypertension and Diabetology, Faculty of Medicine, Medical University of Gdansk, 80 210 Gdansk, Poland
3
Department of Surgery and Anatomy, Ribeirao Preto Medical School, Ribeirão Preto-SP 14049-900, Brazil
4
Division of Biomedical Statistics and Informatics, Mayo Clinic, MN55 905, USA
5
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55 905, USA
*
Author to whom correspondence should be addressed.
Cells 2019, 8(5), 381; https://doi.org/10.3390/cells8050381
Received: 8 February 2019 / Revised: 15 April 2019 / Accepted: 24 April 2019 / Published: 26 April 2019
(This article belongs to the Special Issue The Role of Telomere Biology in Aging and Human Disease)
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Abstract

Telomere length (TL) is associated with cardiovascular disease (CVD) and cancer. Obstructive sleep apnea (OSA) is also linked to higher risk of CVD and cancer, and to TL. We investigated the association between TL and risk of major adverse cardiac events (MACE) and cancer in OSA patients. We studied 210 individuals undergoing sleep-related studies between 2000 and 2007. Baseline characteristics and follow-up data (available in 164 subjects) were obtained from clinic records. Incidence rates were calculated for the entire group and by OSA status. Hazard ratios were calculated to estimate effects of OSA and TL on risk of MACE and cancer. In total, 32 individuals (20%) developed MACE and/or cancer during 12.7-year follow-up. The OSA group had a higher likelihood of cancer (16.0 vs. 4.9 events per 1000 person-years, P = 0.044) but no clear evidence of an elevated incidence of MACE (10.8 vs. 4.8 events per 1000 person-years, P = 0.293) compared to the non-OSA group. There was no association between TL and MACE- (HR = 1.01, 95% CI 0.78–1.28), or cancer-risk (HR = 1.18, 95% CI 0.96–1.43). Our study warrants further investigation of any modulating effect of OSA on TL and the risk of MACE and cancer. View Full-Text
Keywords: obstructive sleep apnea; telomere length; major adverse cardiac events; cancer obstructive sleep apnea; telomere length; major adverse cardiac events; cancer
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Polonis, K.; Sompalli, S.; Becari, C.; Xie, J.; Covassin, N.; Schulte, P.J.; Druliner, B.R.; Johnson, R.A.; Narkiewicz, K.; Boardman, L.A.; Singh, P.; Somers, V.K. Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients. Cells 2019, 8, 381.

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