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Open AccessArticle

Dermatopontin in Skeletal Muscle Extracellular Matrix Regulates Myogenesis

Department of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Korea
School of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University, Rajouri 185236, India
Department of Veterinary Histology, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea
Authors to whom correspondence should be addressed.
Authors contributed equally to this work.
Cells 2019, 8(4), 332;
Received: 19 March 2019 / Revised: 6 April 2019 / Accepted: 9 April 2019 / Published: 9 April 2019
Dermatopontin (DPT) is an extensively distributed non-collagenous component of the extracellular matrix predominantly found in the dermis of the skin, and consequently expressed in several tissues. In this study, we explored the role of DPT in myogenesis and perceived that it enhances the cell adhesion, reduces the cell proliferation and promotes the myoblast differentiation in C2C12 cells. Our results reveal an inhibitory effect with fibronectin (FN) in myoblast differentiation. We also observed that DPT and fibromodulin (FMOD) regulate positively to each other and promote myogenic differentiation. We further predicted the 3D structure of DPT, which is as yet unknown, and validated it using state-of-the-art in silico tools. Furthermore, we explored the in-silico protein-protein interaction between DPT-FMOD, DPT-FN, and FMOD-FN, and perceived that the interaction between FMOD-FN is more robust than DPT-FMOD and DPT-FN. Taken together, our findings have determined the role of DPT at different stages of the myogenic process. View Full-Text
Keywords: dermatopontin; fibromodulin; fibronectin; differentiation; myogenesis; protein-protein interaction dermatopontin; fibromodulin; fibronectin; differentiation; myogenesis; protein-protein interaction
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Kim, T.; Ahmad, K.; Shaikh, S.; Jan, A.T.; Seo, M.-G.; Lee, E.J.; Choi, I. Dermatopontin in Skeletal Muscle Extracellular Matrix Regulates Myogenesis. Cells 2019, 8, 332.

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