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Cells 2019, 8(1), 43; https://doi.org/10.3390/cells8010043

Molecular Mechanisms Related to Hormone Inhibition Resistance in Prostate Cancer

1
Division of Oncology, S. Orsola-Malpighi Hospital, 40138 Bologna, Italy
2
Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, 60126 Ancona, Italy
3
Department of Surgery, Cordoba University Medical School, 14071 Cordoba, Spain
4
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
5
Oncology Unit, Macerata Hospital, 62012 Macerata, Italy
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 7 December 2018 / Revised: 4 January 2019 / Accepted: 8 January 2019 / Published: 11 January 2019
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Cancers: Prostate Cancer)
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Abstract

Management of metastatic or advanced prostate cancer has acquired several therapeutic approaches that have drastically changed the course of the disease. In particular due to the high sensitivity of prostate cancer cells to hormone depletion, several agents able to inhibit hormone production or binding to nuclear receptor have been evaluated and adopted in clinical practice. However, despite several hormonal treatments being available nowadays for the management of advanced or metastatic prostate cancer, the natural history of the disease leads inexorably to the development of resistance to hormone inhibition. Findings regarding the mechanisms that drive this process are of particular and increasing interest as these are potentially related to the identification of new targetable pathways and to the development of new drugs able to improve our patients’ clinical outcomes. View Full-Text
Keywords: hormone inhibition resistance; prostate cancer (PCa), castration-resistance PCa; AR splice variants; epigenetic mechanisms hormone inhibition resistance; prostate cancer (PCa), castration-resistance PCa; AR splice variants; epigenetic mechanisms
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Mollica, V.; Di Nunno, V.; Cimadamore, A.; Lopez-Beltran, A.; Cheng, L.; Santoni, M.; Scarpelli, M.; Montironi, R.; Massari, F. Molecular Mechanisms Related to Hormone Inhibition Resistance in Prostate Cancer. Cells 2019, 8, 43.

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