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Cells
Volume 10
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10.3390/cells10051025
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Review

Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia

by
Jana Krystofova Mike
1,* and
Donna Marie Ferriero
1,2
1
Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143, USA
2
Department of Neurology Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94143, USA
*
Author to whom correspondence should be addressed.
Cells 2021, 10(5), 1025; https://doi.org/10.3390/cells10051025
Submission received: 31 March 2021 / Revised: 22 April 2021 / Accepted: 23 April 2021 / Published: 27 April 2021
(This article belongs to the Special Issue Mechanisms of Cell Death in Neonatal Brain Injury)
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Abstract

Neonatal brain hypoxia-ischemia (HI) is a leading cause of morbidity and long-term disabilities in children. While we have made significant progress in describing HI mechanisms, the limited therapies currently offered for HI treatment in the clinical setting stress the importance of discovering new targetable pathways. Efferocytosis is an immunoregulatory and homeostatic process of clearance of apoptotic cells (AC) and cellular debris, best described in the brain during neurodevelopment. The therapeutic potential of stimulating defective efferocytosis has been recognized in neurodegenerative diseases. In this review, we will explore the involvement of efferocytosis after a stroke and HI as a promising target for new HI therapies.
Keywords: efferocytosis; stroke; neonatal brain efferocytosis; stroke; neonatal brain

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MDPI and ACS Style

Mike, J.K.; Ferriero, D.M. Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia. Cells 2021, 10, 1025. https://doi.org/10.3390/cells10051025

AMA Style

Mike JK, Ferriero DM. Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia. Cells. 2021; 10(5):1025. https://doi.org/10.3390/cells10051025

Chicago/Turabian Style

Mike, Jana Krystofova, and Donna Marie Ferriero. 2021. "Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia" Cells 10, no. 5: 1025. https://doi.org/10.3390/cells10051025

APA Style

Mike, J. K., & Ferriero, D. M. (2021). Efferocytosis Mediated Modulation of Injury after Neonatal Brain Hypoxia-Ischemia. Cells, 10(5), 1025. https://doi.org/10.3390/cells10051025

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