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Fibroblast Memory in Development, Homeostasis and Disease

Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
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Academic Editor: Alessandro Poggi
Cells 2021, 10(11), 2840; https://doi.org/10.3390/cells10112840
Received: 24 September 2021 / Revised: 19 October 2021 / Accepted: 20 October 2021 / Published: 22 October 2021
(This article belongs to the Collection Feature Papers in Cellular Immunology)
Fibroblasts are the major cell population in the connective tissue of most organs, where they are essential for their structural integrity. They are best known for their role in remodelling the extracellular matrix, however more recently they have been recognised as a functionally highly diverse cell population that constantly responds and adapts to their environment. Biological memory is the process of a sustained altered cellular state and functions in response to a transient or persistent environmental stimulus. While it is well established that fibroblasts retain a memory of their anatomical location, how other environmental stimuli influence fibroblast behaviour and function is less clear. The ability of fibroblasts to respond and memorise different environmental stimuli is essential for tissue development and homeostasis and may become dysregulated in chronic disease conditions such as fibrosis and cancer. Here we summarise the four emerging key areas of fibroblast adaptation: positional, mechanical, inflammatory, and metabolic memory and highlight the underlying mechanisms and their implications in tissue homeostasis and disease. View Full-Text
Keywords: biological memory; fibroblasts; wound healing; fibrosis; cancer; inflammation; metabolism; positional identity; epigenetic modification; mechanical stress; cell fate biological memory; fibroblasts; wound healing; fibrosis; cancer; inflammation; metabolism; positional identity; epigenetic modification; mechanical stress; cell fate
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MDPI and ACS Style

Kirk, T.; Ahmed, A.; Rognoni, E. Fibroblast Memory in Development, Homeostasis and Disease. Cells 2021, 10, 2840. https://doi.org/10.3390/cells10112840

AMA Style

Kirk T, Ahmed A, Rognoni E. Fibroblast Memory in Development, Homeostasis and Disease. Cells. 2021; 10(11):2840. https://doi.org/10.3390/cells10112840

Chicago/Turabian Style

Kirk, Thomas, Abubkr Ahmed, and Emanuel Rognoni. 2021. "Fibroblast Memory in Development, Homeostasis and Disease" Cells 10, no. 11: 2840. https://doi.org/10.3390/cells10112840

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