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Article

Single-Cell Proteomic Profiling Identifies Nanoparticle Enhanced Therapy for Triple Negative Breast Cancer Stem Cells

Harbin Medical University Cancer Hospital, Cancer Research Institute, Harbin Medical University, Harbin 150081, China
*
Authors to whom correspondence should be addressed.
The authors contributed equally as co-first authors.
Academic Editors: Ming Luo and Kermit L. Carraway
Cells 2021, 10(11), 2842; https://doi.org/10.3390/cells10112842
Received: 30 August 2021 / Revised: 9 October 2021 / Accepted: 19 October 2021 / Published: 22 October 2021
(This article belongs to the Special Issue Targeting Cancer Stem Cell)
Breast cancer remains a major cause of cancer-related deaths in women worldwide. Chemotherapy-promoted stemness and enhanced stem cell plasticity in breast cancer is a cause for great concern. The discovery of drugs targeting BCSCs was suggested to be an important advancement in the establishment of therapy that improves the efficacy of chemotherapy. In this work, by using single-cell mass cytometry, we observed that stemness in spheroid-forming cells derived from MDA-MB-231 cells was significantly increased after doxorubicin administration and up-regulated integrin αvβ3 expression was also observed. An RGD-included nanoparticle (CS-V) was designed, and it was found that it could promote doxorubicin’s efficacy against MDA-MB-231 spheroid cells. The above observations suggested that the combination of RGD-included nanoparticles (CS-V) with the chemo-drug doxorubicin could be developed as a potential therapy for breast cancer. View Full-Text
Keywords: chitosan nanoparticle; spheroid cells; integrins chitosan nanoparticle; spheroid cells; integrins
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MDPI and ACS Style

Wang, W.; Lei, B.; Li, L.; Liu, J.; Li, Z.; Pang, Y.; Liu, T.; Li, Z. Single-Cell Proteomic Profiling Identifies Nanoparticle Enhanced Therapy for Triple Negative Breast Cancer Stem Cells. Cells 2021, 10, 2842. https://doi.org/10.3390/cells10112842

AMA Style

Wang W, Lei B, Li L, Liu J, Li Z, Pang Y, Liu T, Li Z. Single-Cell Proteomic Profiling Identifies Nanoparticle Enhanced Therapy for Triple Negative Breast Cancer Stem Cells. Cells. 2021; 10(11):2842. https://doi.org/10.3390/cells10112842

Chicago/Turabian Style

Wang, Wenzheng, Bo Lei, Lin Li, Jianyu Liu, Zhihui Li, Yuheng Pang, Tong Liu, and Zhigao Li. 2021. "Single-Cell Proteomic Profiling Identifies Nanoparticle Enhanced Therapy for Triple Negative Breast Cancer Stem Cells" Cells 10, no. 11: 2842. https://doi.org/10.3390/cells10112842

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