Review Reports

Round 1

Reviewer 1 Report

Zhang et al. review the literature on the process and mechanisms of tissue restoration/regeneration after ICH. The literature review is well written and thorough well done. A "Table" summarizes the strategies to promote neural regeneration after ICH (including medications & cell therapy)  will strengthen this review article. 

Author Response

Thank you for the comment that the  review is well written and thorough. We have now included a table that summarizes the strategies to promote neural regeneration after ICH. It is currently placed under line 433 in the text.

We agree that the table improves the readability of the review, as one can refer to that quickly.   

Reviewer 2 Report

The reviewer is neurosurgeon with intimate relationship to the ICH, especially how to minimize  primary trauma after stroke via minimally invasive approaches and he is preferring urgent surgery, because big part of hematomas show tendency to growth in volume. Stroke protocol is widely  spread around the world and  this fact allows  early treatment also for hemorrhagic types of stroke.

But   how to minimize secondary trauma of brain tissue and  how to support effective regeneration of brain tissue is out of neurosurgical possibilities.

Authors review brings nice overview about  state of art in this field and could be  helpful for people interesting for this topic. Socially and economically independent patient after ICH is still  the run to the long distance, but this review  could be  for somebody first step in this field.

 

 

Author Response

Thank you for the favourable comment that this review brings a good  overview about the state of the art in the field of repair in intracerebral hemorrhage. 

We have addressed the concern of Reviewer 1 and have added a table that now improves readability. 

We appreciate your endorsement.