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Article

Characterization of Epigallocatechin-Gallate-Grafted Chitosan Nanoparticles and Evaluation of Their Antibacterial and Antioxidant Potential

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Departamento de Ciencias Químico Biológicas, Universidad de Sonora, 83000 Hermosillo, Sonora, Mexico
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Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, 83000 Hermosillo, Sonora, Mexico
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Departamento de Procesos de Transformación de Plásticos, Centro de Investigación en Química Aplicada, 25294 Saltillo, Coahuila, Mexico
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Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, 83000 Hermosillo, Sonora, Mexico
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Departamento de Ciencias de la Salud, Universidad de Sonora, 85040 Cd. Obregón, Sonora, Mexico
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Authors to whom correspondence should be addressed.
Academic Editor: Annamaria Visco
Polymers 2021, 13(9), 1375; https://doi.org/10.3390/polym13091375
Received: 22 March 2021 / Revised: 16 April 2021 / Accepted: 19 April 2021 / Published: 23 April 2021
Nanoparticles based on chitosan modified with epigallocatechin gallate (EGCG) were synthetized by nanoprecipitation (EGCG-g-chitosan-P). Chitosan was modified by free-radical-induced grafting, which was verified by Fourier transform infrared (FTIR). Furthermore, the morphology, particle size, polydispersity index, and zeta potential of the nanoparticles were investigated. The grafting degree of EGCG, reactive oxygen species (ROS) production, antibacterial and antioxidant activities of EGCG-g-chitosan-P were evaluated and compared with those of pure EGCG and chitosan nanoparticles (Chitosan-P). FTIR results confirmed the modification of the chitosan with EGCG. The EGCG-g-chitosan-P showed spherical shapes and smoother surfaces than those of Chitosan-P. EGCG content of the grafted chitosan nanoparticles was 330 μg/g. Minimal inhibitory concentration (MIC) of EGCG-g-chitosan-P (15.6 μg/mL) was lower than Chitosan-P (31.2 μg/mL) and EGCG (500 μg/mL) against Pseudomonas fluorescens (p < 0.05). Additionally, EGCG-g-chitosan-P and Chitosan-P presented higher Staphylococcus aureus growth inhibition (100%) than EGCG at the lowest concentration tested. The nanoparticles produced an increase of ROS (p < 0.05) in both bacterial species assayed. Furthermore, EGCG-g-chitosan-P exhibited higher antioxidant activity than that of Chitosan-P (p < 0.05) in 2,2′-azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and ferric-reducing antioxidant power assays. Based on the above results, EGCG-g-chitosan-P shows the potential for food packaging and biomedical applications. View Full-Text
Keywords: nanoparticles; modified chitosan; grafted chitosan; epigallocatechin gallate; antibacterial; antioxidant nanoparticles; modified chitosan; grafted chitosan; epigallocatechin gallate; antibacterial; antioxidant
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MDPI and ACS Style

Moreno-Vásquez, M.J.; Plascencia-Jatomea, M.; Sánchez-Valdes, S.; Tanori-Córdova, J.C.; Castillo-Yañez, F.J.; Quintero-Reyes, I.E.; Graciano-Verdugo, A.Z. Characterization of Epigallocatechin-Gallate-Grafted Chitosan Nanoparticles and Evaluation of Their Antibacterial and Antioxidant Potential. Polymers 2021, 13, 1375. https://doi.org/10.3390/polym13091375

AMA Style

Moreno-Vásquez MJ, Plascencia-Jatomea M, Sánchez-Valdes S, Tanori-Córdova JC, Castillo-Yañez FJ, Quintero-Reyes IE, Graciano-Verdugo AZ. Characterization of Epigallocatechin-Gallate-Grafted Chitosan Nanoparticles and Evaluation of Their Antibacterial and Antioxidant Potential. Polymers. 2021; 13(9):1375. https://doi.org/10.3390/polym13091375

Chicago/Turabian Style

Moreno-Vásquez, María J., Maribel Plascencia-Jatomea, Saúl Sánchez-Valdes, Judith C. Tanori-Córdova, Francisco J. Castillo-Yañez, Idania E. Quintero-Reyes, and Abril Z. Graciano-Verdugo 2021. "Characterization of Epigallocatechin-Gallate-Grafted Chitosan Nanoparticles and Evaluation of Their Antibacterial and Antioxidant Potential" Polymers 13, no. 9: 1375. https://doi.org/10.3390/polym13091375

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