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Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy

1
Inorganic Chemistry Dept., Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 8 Ion Creangă St., 400010 Cluj-Napoca, Romania
2
Analytical Chemistry Dept., Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 4 Pasteur St., 400349 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Polymers 2019, 11(12), 2085; https://doi.org/10.3390/polym11122085
Received: 14 November 2019 / Revised: 3 December 2019 / Accepted: 11 December 2019 / Published: 13 December 2019
(This article belongs to the Special Issue Molecular Imprinted Polymers: Challenges and Applications)
Despite the considerable effort made in the past decades, multiple aspects of cancer management remain a challenge for the scientific community. The severe toxicity and poor bioavailability of conventional chemotherapeutics, and the multidrug resistance have turned the attention of researchers towards the quest of drug carriers engineered to offer an efficient, localized, temporized, and doze-controlled delivery of antitumor agents of proven clinical value. Molecular imprinting of chemotherapeutics is very appealing in the design of drug delivery systems since the specific and selective binding sites created within the polymeric matrix turn these complex structures into value-added carriers with tunable features, notably high loading capacity, and a good control of payload release. Our work aims to summarize the present state-of-the art of molecularly imprinted polymer-based drug delivery systems developed for anticancer therapy, with emphasis on the particularities of the chemotherapeutics’ release and with a critical assessment of the current challenges and future perspectives of these unique drug carriers. View Full-Text
Keywords: molecularly imprinted polymers; chemotherapeutics; cancer therapy; drug delivery systems molecularly imprinted polymers; chemotherapeutics; cancer therapy; drug delivery systems
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Bodoki, A.E.; Iacob, B.-C.; Bodoki, E. Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy. Polymers 2019, 11, 2085.

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