Review Reports
- David Zaragoza-Huesca1,
- Andrés Nieto-Olivares2 and
- Francisco García-Molina3
- et al.
Reviewer 1: Joanna Matowicka-Karna Reviewer 2: Anonymous Reviewer 3: Anonymous
Round 1
Reviewer 1 Report
The limitations of this study:
1. Too small number of patients in the study group (only 287 patients with CRC),
2. Thrombosis very often accompanies cancer,
3. A single center study was conducted.
Author Response
We want to thank the comments of the reviewer. We have incorporated the limitations found by the reviewer in the main manuscript:
Among the limitations of this study, the first is the unique origin of the recruited patients, since they all belong to the same geographical area (Murcia Region, Spain), so the extrapolation of these results to larger cohorts from other distant geographical areas must be confirmed. The second limitation refers to the results regarding HPN as a thrombotic biomarker. Although the differences in the cumulative incidence of thrombosis are significant according to the expression of this protein in the primary tumor biopsy, thrombosis, which very often accompanies cancer, has a multifactorial etiology that involves not only genetic factors but also numerous environmental factors that could interfere with the usefulness of HPN as a biomarker.
Reviewer 2 Report
The manuscript entitled "Implication of Hepsin from primary tumor in the prognosis of colorectal cancer patients" of Zaragoza-Huesca et al., is well written, well organized and of great interest. I suggest this work for publication.
Author Response
We would like to thank the reviewer for the kind words.
Reviewer 3 Report
Authors did well described the "Implication of Hepsin from primary tumor in the prognosis of colorectal cancer patients".
I do not feel any points that should be corrected.
Thus this paper could be published in current style.
Author Response
We would like to thank the reviewer for the kind words.