Next Article in Journal
The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities
Next Article in Special Issue
Uncommon Site of Metastasis and Prolonged Survival in Patients with Anaplastic Thyroid Carcinoma: A Systematic Review of the Literature
Previous Article in Journal
From Interconnection between Genes and Microenvironment to Novel Immunotherapeutic Approaches in Upper Gastro-Intestinal Cancers—A Multidisciplinary Perspective
Previous Article in Special Issue
Aberrant Expression of Androgen Receptor Associated with High Cancer Risk and Extrathyroidal Extension in Papillary Thyroid Carcinoma
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cancers
Volume 12
Issue 8
10.3390/cancers12082104
Review Report
cancers-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Review
Peer-Review Record

Novel Targeted Therapies for Metastatic Thyroid Cancer—A Comprehensive Review

Cancers 2020, 12(8), 2104; https://doi.org/10.3390/cancers12082104
by Mohammad Al-Jundi †, Shilpa Thakur †, Sriram Gubbi and Joanna Klubo-Gwiezdzinska *
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Cancers 2020, 12(8), 2104; https://doi.org/10.3390/cancers12082104
Submission received: 14 July 2020 / Revised: 22 July 2020 / Accepted: 25 July 2020 / Published: 29 July 2020
(This article belongs to the Special Issue Thyroid Cancer Metastases (Biological and Clinical Aspects))

Round 1

Reviewer 1 Report

The manuscript has been greatly improved

Author Response

Dear reviewer,

Thank you for your contribution in reviewing our article.

Reviewer 2 Report

I received the revised manuscript.

Even if improved, some inaccuracies are also present.

Line 131: the sentence is not clear (MTC?).

In the section about RET mutations, probably it should be useful to distinguish the subtypes of MEN syndromes and the genotype-phenotype correlation.

Table 1 can be improved. Please consider to consult the recently published paper:  10.1080/17460441.2020.1674280. 

Author Response

July 21, 2020

 

Dear Editors,

Thank you for considering our review article entitled “Novel Targeted Therapies for Metastatic Thyroid Cancer -a Comprehensive Review” for publication in Cancers. 

We kindly thank the Reviewer for the critical analysis of the article. We have incorporated the changes, as recommended. The changes have been highlighted through “tracked changes” in the manuscript.  We believe that the paper is now suitable for publication in Cancers.

Here is our point by point response to the reviewer’s comments:

Comment- Line 131: the sentence is not clear (MTC?).

Reply- We apologize for the lack of clarity in this statement. The sentence has been corrected to indicate that RET fusions are observed in papillary thyroid cancer (PTC) (line 131, Page 5)

Comment- In the section about RET mutations, probably it should be useful to distinguish the subtypes of MEN syndromes and the genotype-phenotype correlation.

Reply- Thank you for the comment. As per your suggestion, we have incorporated the information related to the subtypes of MEN syndromes and the genotype-phenotype correlation (line 166, page 6).

Comment- Table 1 can be improved. Please consider to consult the recently published paper:  10.1080/17460441.2020.1674280.

Reply- Thank you for the suggestion. Table 1 has been corrected to include more information on the nature of molecular alterations, estimated frequency of mutations in different types of thyroid cancer (when available), and the biological role of particular mutations in thyroid cancer.

Back to TopTop