Next Article in Journal
Macrophages in Colorectal Cancer Liver Metastases
Next Article in Special Issue
Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems
Previous Article in Journal
Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion
Previous Article in Special Issue
Recent Progress in the Theranostics Application of Nanomedicine in Lung Cancer
Article Menu

Export Article

Open AccessReview

Oncogenic Signaling in Tumorigenesis and Applications of siRNA Nanotherapeutics in Breast Cancer

1
Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
2
Centre for Virus and Vaccine Research (CVVR), Sunway University, 47500 Subang Jaya, Selangor, Malaysia
3
Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, 47500 Subang Jaya, Selangor, Malaysia
*
Author to whom correspondence should be addressed.
Cancers 2019, 11(5), 632; https://doi.org/10.3390/cancers11050632
Received: 21 February 2019 / Revised: 6 April 2019 / Accepted: 8 April 2019 / Published: 6 May 2019
(This article belongs to the Special Issue Cancer Nanomedicine)
  |  
PDF [1816 KB, uploaded 7 May 2019]
  |     |  

Abstract

Overexpression of oncogenes and cross-talks of the oncoproteins-regulated signaling cascades with other intracellular pathways in breast cancer could lead to massive abnormal signaling with the consequence of tumorigenesis. The ability to identify the genes having vital roles in cancer development would give a promising therapeutics strategy in combating the disease. Genetic manipulations through siRNAs targeting the complementary sequence of the oncogenic mRNA in breast cancer is one of the promising approaches that can be harnessed to develop more efficient treatments for breast cancer. In this review, we highlighted the effects of major signaling pathways stimulated by oncogene products on breast tumorigenesis and discussed the potential therapeutic strategies for targeted delivery of siRNAs with nanoparticles in suppressing the stimulated signaling pathways. View Full-Text
Keywords: breast cancer; siRNA; cell signaling; active targeting; passive targeting; EPR effect; oncogenes; nanoparticles; nanomedicine breast cancer; siRNA; cell signaling; active targeting; passive targeting; EPR effect; oncogenes; nanoparticles; nanomedicine
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Kamaruzman, N.I.; Aziz, N.A.; Poh, C.L.; Chowdhury, E.H. Oncogenic Signaling in Tumorigenesis and Applications of siRNA Nanotherapeutics in Breast Cancer. Cancers 2019, 11, 632.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top