Lipidomic and Antioxidant Response to Grape Seed, Corn and Coconut Oils in Healthy Wistar Rats
by
Abraham Wall-Medrano 1,*
, Laura A. De la Rosa 1,*, Alma A. Vázquez-Flores 1, Gilberto Mercado-Mercado 1, Rogelio González-Arellanes 1, José A. López-Díaz 1, Aarón F. González-Córdova 2, Gustavo A. González-Aguilar 3, Belinda Vallejo-Cordoba 2 and Francisco J. Molina-Corral 4
Abraham Wall-Medrano 1,*, Laura A. De la Rosa 1,*, Alma A. Vázquez-Flores 1, Gilberto Mercado-Mercado 1, Rogelio González-Arellanes 1, José A. López-Díaz 1, Aarón F. González-Córdova 2, Gustavo A. González-Aguilar 3, Belinda Vallejo-Cordoba 2 and Francisco J. Molina-Corral 4
1
Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo Envolvente del PRONAF y Estocolmo s/n, Ciudad Juárez 32310, Chihuahua, Mexico
2
Centro de Investigación en Alimentación y Desarrollo, AC (Unidad Hermosillo), Coordinación de Tecnología de Alimentos de Origen Animal (DTAOA), Carretera a la Victoria km. 0.6, AP 1735, Hermosillo 83000, Sonora, Mexico
3
Centro de Investigación en Alimentación y Desarrollo, AC (Unidad Hermosillo), Tecnología de Alimentos de Origen Vegetal (DTAOV), Carretera a la Victoria km. 0.6, AP 1735, Hermosillo 83000, Sonora, Mexico
4
Centro de Investigación en Alimentación y Desarrollo, AC. (Unidad Cuauhtémoc), Laboratorio de Tecnología de Alimentos de Origen Vegetal y Toxicología, Ave. Río Conchos s/n, Parque Industrial, AP 781, Cuauhtémoc 31570, Chihuahua, Mexico
*
Authors to whom correspondence should be addressed.
Nutrients 2017, 9(1), 82; https://doi.org/10.3390/nu9010082
Received: 5 November 2016 / Revised: 28 December 2016 / Accepted: 11 January 2017 / Published: 20 January 2017
(This article belongs to the Special Issue Nutrigenetics)
Specialty oils differ in fatty acid, phytosterol and antioxidant content, impacting their benefits for cardiovascular health. The lipid (fatty acid, phytosterol) and antioxidant (total phenolics, radical scavenging capacity) profiles of grapeseed (GSO), corn (CO) and coconut (CNO) oils and their physiological (triacylglycerides, total and HDL-cholesterol and antioxidant capacity (FRAP) in serum and fatty acid and phytosterol hepatic deposition) and genomic (HL, LCAT, ApoA-1 and SR-BP1 mRNA hepatic levels) responses after their sub-chronic intake (10% diet for 28 days) was examined in healthy albino rats. Fatty acid, phytosterol and antioxidant profiles differed between oils (p ≤ 0.01). Serum and hepatic triacylglycerides and total cholesterol increased (p ≤ 0.01); serum HDL-Cholesterol decreased (p < 0.05); but serum FRAP did not differ (p > 0.05) in CNO-fed rats as compared to CO or GSO groups. Hepatic phytosterol deposition was higher (+2.2 mg/g; p ≤ 0.001) in CO- than GSO-fed rats, but their fatty acid deposition was similar. All but ApoA-1 mRNA level increased in GSO-fed rats as compared to other groups (p ≤ 0.01). Hepatic fatty acid handling, but not antioxidant response, nor hepatic phytosterol deposition, could be related to a more efficient reverse-cholesterol transport in GSO-fed rats as compared to CO or CNO.
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Keywords:
specialty oil; fatty acids; grapeseed oil; antioxidant; HDL; coconut oil; corn oil; lipoproteins; phytosterols
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MDPI and ACS Style
Wall-Medrano, A.; De la Rosa, L.A.; Vázquez-Flores, A.A.; Mercado-Mercado, G.; González-Arellanes, R.; López-Díaz, J.A.; González-Córdova, A.F.; González-Aguilar, G.A.; Vallejo-Cordoba, B.; Molina-Corral, F.J. Lipidomic and Antioxidant Response to Grape Seed, Corn and Coconut Oils in Healthy Wistar Rats. Nutrients 2017, 9, 82.
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