Next Article in Journal
Mediterranean Diet and Phase Angle in a Sample of Adult Population: Results of a Pilot Study
Next Article in Special Issue
Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention
Previous Article in Journal
Effect of Fibre Supplementation on Body Weight and Composition, Frequency of Eating and Dietary Choice in Overweight Individuals
Previous Article in Special Issue
Lipidomic and Antioxidant Response to Grape Seed, Corn and Coconut Oils in Healthy Wistar Rats
Open AccessReview

Genetic Variations as Modifying Factors to Dietary Zinc Requirements—A Systematic Review

Department of Nutrition, Dietetics and Food, Monash University, Notting Hill VIC 3168, Australia
Author to whom correspondence should be addressed.
Current address: School of Biomedical Sciences, University of Surrey, Guilford, Surrey, UK.
These authors contribute equally to this work.
Nutrients 2017, 9(2), 148;
Received: 11 January 2017 / Revised: 9 February 2017 / Accepted: 13 February 2017 / Published: 17 February 2017
(This article belongs to the Special Issue Nutrigenetics)
Due to reduced cost and accessibility, the use of genetic testing has appealed to health professionals for personalising nutrition advice. However, translation of the evidence linking polymorphisms, dietary requirements, and pathology risk proves to be challenging for nutrition and dietetic practitioners. Zinc status and polymorphisms of genes coding for zinc-transporters have been associated with chronic diseases. The present study aimed to systematically review the literature to assess whether recommendations for zinc intake could be made according to genotype. Eighteen studies investigating 31 Single Nucleotide Polymorphisms (SNPs) in relation to zinc intake and/or status were identified. Five studies examined type 2 diabetes; zinc intake was found to interact independently with two polymorphisms in the zinc-transporter gene SLC30A8 to affect glucose metabolism indicators. While the outcomes were statistically significant, the small size of the effect and lack of replication raises issues regarding translation into nutrition and dietetic practice. Two studies assessed the relationship of polymorphisms and cognitive performance; seven studies assessed the association between a range of outcomes linked to chronic conditions in aging population; two papers described the analysis of the genetic contribution in determining zinc concentration in human milk; and two papers assessed zinc concentration in plasma without linking to clinical outcomes. The data extracted confirmed a connection between genetics and zinc requirements, although the direction and magnitude of the dietary modification for carriers of specific genotypes could not be defined. This study highlights the need to summarise nutrigenetics studies to enable health professionals to translate scientific evidence into dietary recommendations. View Full-Text
Keywords: zinc requirements; SNPs; nutrigenetics; nutritional genomics zinc requirements; SNPs; nutrigenetics; nutritional genomics
Show Figures

Figure 1

MDPI and ACS Style

Day, K.J.; Adamski, M.M.; Dordevic, A.L.; Murgia, C. Genetic Variations as Modifying Factors to Dietary Zinc Requirements—A Systematic Review. Nutrients 2017, 9, 148.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop