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Nutrients 2016, 8(8), 491;

Improvement of Triglyceride Levels through the Intake of Enriched-β-Conglycinin Soybean (Nanahomare) Revealed in a Randomized, Double-Blind, Placebo-Controlled Study

Department of Medical Management and Informatics, Hokkaido Information University, Ebetsu, Hokkaido 069-8585, Japan
Division of Food Function Research, Food Research Institute, NARO, Tsukuba, Ibaraki 305-8642, Japan
Institute of Crop Science, NARO, Tsukuba, Ibaraki 305-8518, Japan
Author to whom correspondence should be addressed.
Received: 13 June 2016 / Revised: 3 August 2016 / Accepted: 5 August 2016 / Published: 11 August 2016
(This article belongs to the Special Issue Health Benefits of Soybean and other Grain Legumes)
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Soybean is recognized as a beneficial food with various functional components, such as β-conglycinin, which improves lipid metabolism. We evaluated the effects of the β-conglycinin-rich soybean Nanahomare on triglyceride (TG) levels. In this randomized, double-blind, placebo-controlled study, we divided 134 adult subjects into test and placebo groups that consumed processed food containing enriched-β-conglycinin soybean or low-β-conglycinin soybean. Hematological tests and body composition measurements were performed at weeks 0 (baseline), 4, 8, and 12 of the study period. TG levels significantly decreased in the test group compared with the placebo group at weeks 4 (change from baseline to week 4, placebo: 0.27 ± 44.13 mg/dL, test: −20.31 ± 43.74 mg/dL, p = 0.035) and 12 (change from baseline to week 12, placebo: −0.14 ± 65.83 mg/dL, test: −21.30 ± 46.21 mg/dL, p = 0.041). In addition, among subjects whose baseline TG levels were ≥100 mg/dL, the levels significantly improved in the test group at weeks 4 (p = 0.010) and 12 (p = 0.030), whereas the levels were not different between the test and placebo groups among those whose baseline levels were <100 mg/dL. These results suggest that the ingestion of enriched-β-conglycinin soybean improves serum TG levels. View Full-Text
Keywords: clinical trial; Nanahomare; soybean; triglyceride; β-conglycinin clinical trial; Nanahomare; soybean; triglyceride; β-conglycinin

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Nishimura, M.; Ohkawara, T.; Sato, Y.; Satoh, H.; Takahashi, Y.; Hajika, M.; Nishihira, J. Improvement of Triglyceride Levels through the Intake of Enriched-β-Conglycinin Soybean (Nanahomare) Revealed in a Randomized, Double-Blind, Placebo-Controlled Study. Nutrients 2016, 8, 491.

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