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Open AccessArticle

Inhibition of Pancreatic Lipase and Triacylglycerol Intestinal Absorption by a Pinhão Coat (Araucaria angustifolia) Extract Rich in Condensed Tannin

1
Department of Biochemistry, State University of Maringá, Maringá 87020900, Brazil
2
Instituto Federal do Paraná, Jacarezinho 86400000, Brazil
3
Department of Nutrition, Federal University of the South Border, Realeza 85770000, Brazil
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2015, 7(7), 5601-5614; https://doi.org/10.3390/nu7075242
Received: 28 April 2015 / Revised: 27 May 2015 / Accepted: 30 June 2015 / Published: 9 July 2015
(This article belongs to the Special Issue Natural Products for Human Health)
The purpose of the present work was to characterize the possible inhibition of pancreatic lipase by a tannin-rich extract obtained from the pinhão (Araucaria angustifolia seed) coat, based on the previous observation that this preparation inhibits α-amylases. Kinetic measurements of pancreatic lipase revealed that the pinhão coat tannin is an effective inhibitor. Inhibition was of the parabolic non-competitive type. The inhibition constants, \({\overline{K}}_{i1} \) and \({\overline{K}}_{i2} \), were equal to 332.7 ± 146.1 µg/mL and 321.2 \(\pm\) 93.0 µg/mL, respectively, corresponding roughly to the inhibitor concentration producing 50. View Full-Text
Keywords: tannins; lipase; enzyme; obesity tannins; lipase; enzyme; obesity
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Oliveira, R.F.; Gonçalves, G.A.; Inácio, F.D.; Koehnlein, E.A.; De Souza, C.G.M.; Bracht, A.; Peralta, R.M. Inhibition of Pancreatic Lipase and Triacylglycerol Intestinal Absorption by a Pinhão Coat (Araucaria angustifolia) Extract Rich in Condensed Tannin. Nutrients 2015, 7, 5601-5614.

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