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Open AccessArticle

Glucose Homeostasis Variables in Pregnancy versus Maternal and Infant Body Composition

Department of Clinical and Experimental Medicine, Linköping University, Linköping SE 581 85, Sweden
Department of Biosciences and Nutrition, Karolinska Institute, NOVUM, Huddinge SE 141 83, Sweden
Author to whom correspondence should be addressed.
Nutrients 2015, 7(7), 5615-5627;
Received: 21 May 2015 / Revised: 24 June 2015 / Accepted: 2 July 2015 / Published: 10 July 2015
Intrauterine factors influence infant size and body composition but the mechanisms involved are to a large extent unknown. We studied relationships between the body composition of pregnant women and variables related to their glucose homeostasis, i.e., glucose, HOMA-IR (homeostasis model assessment-insulin resistance), hemoglobin A1c and IGFBP-1 (insulin-like growth factor binding protein-1), and related these variables to the body composition of their infants. Body composition of 209 women in gestational week 32 and of their healthy, singleton and full-term one-week-old infants was measured using air displacement plethysmography. Glucose homeostasis variables were assessed in gestational week 32. HOMA-IR was positively related to fat mass index and fat mass (r2 = 0.32, p < 0.001) of the women. Maternal glucose and HOMA-IR values were positively (p ≤ 0.006) associated, while IGFBP-1was negatively (p = 0.001) associated, with infant fat mass. HOMA-IR was positively associated with fat mass of daughters (p < 0.001), but not of sons (p = 0.65) (Sex-interaction: p = 0.042). In conclusion, glucose homeostasis variables of pregnant women are related to their own body composition and to that of their infants. The results suggest that a previously identified relationship between fat mass of mothers and daughters is mediated by maternal insulin resistance. View Full-Text
Keywords: body composition; infant; insulin resistance; pregnancy; sex difference body composition; infant; insulin resistance; pregnancy; sex difference
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Henriksson, P.; Löf, M.; Forsum, E. Glucose Homeostasis Variables in Pregnancy versus Maternal and Infant Body Composition. Nutrients 2015, 7, 5615-5627.

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