Next Article in Journal
Longitudinal Interaction Between Individualized Gut Microbial Dynamics and Diet Is Associated with Metabolic Health in School-Aged Children
Next Article in Special Issue
Integrating Sensory Perception and Wearable Monitoring to Promote Healthy Aging: A New Frontier in Nutritional Personalization
Previous Article in Journal
The Changing Landscape of Sodium Needs in the Preterm Neonate for Optimizing Growth and Development
Previous Article in Special Issue
Activation of Sirtuin3 by 6,4′-Dihydroxy-7-methoxyflavanone Against Myoblasts Senescence by Attenuating D-Galactose-Induced Oxidative Stress and Inflammation
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 18
Issue 2
10.3390/nu18020185
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Plasma Phospholipid Biomarkers Related to the Risk of Cognitive Decline in the Elderly: Results from a Cohort Study

by
Ting-Ting Liu
1,†,
Jia-Wei Xie
1,†,
Xin Long
2,†,
Xin-Can Yu
2,†,
Shan-Shan Jia
1,
Qing-Qing Man
1,
Jing Li
3,
Pu-Jun Quan
2,
Ke-Chang Shan
2,
Jian Zhang
1,
Shuang Song
1,4,* and
Dan Liu
2,*
1
National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China
2
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China
3
Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, China
4
Key Laboratory of Public Nutrition and Health, National Health Commission of the People’s Republic of China, Beijing 100050, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2026, 18(2), 185; https://doi.org/10.3390/nu18020185
Submission received: 6 December 2025 / Revised: 23 December 2025 / Accepted: 24 December 2025 / Published: 6 January 2026
(This article belongs to the Special Issue Nutrient Interaction, Metabolic Adaptation and Healthy Aging)
Browse Figures
Versions Notes

Abstract

Phospholipids provide both structural and functional varieties for neuro cells, and their dysregulation in brain has been related to pathogenesis of cognitive impairment. The reflection of these phospholipid alterations in the blood might serve as biomarkers for the early recognition of cognitive decline risk preceding clinical symptoms and provide potential targets for intervention. In this cohort study, detailed phospholipid molecular profiles including 229 species were quantified. A total of 209 participants aged 60–80 years (including 138 women and 73 men) were followed for one year, during which 32 participants developed significant cognitive decline, defined as a decrease of three or more points in the Montreal Cognitive Assessment score. A biomarker panel of eight phospholipid molecular species related to cognitive decline was identified by Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression between cases and non-cases. Among these, four biomarkers, including PE(O-40:5), LPC(18:3), PI(38:2) and PA(39:4), were further proved to be significantly associated with the risk of cognitive decline through a logistic regression model, indicating that the degradation of phospholipids and the accumulation of ether phospholipid and PI might participate in the process of cognitive decline in early stage. By adding the eight phospholipid biomarkers to a reference model that included demographics, lifestyle, hypertension, fasting blood glucose and blood lipid parameters, the AUC value of the predictive model improved from 0.743 to 0.866, which provided a possible auxiliary screening tool for the early detection of cognitive impairment in the elderly.
Keywords: phospholipid; biomarker; cognitive decline risk; cohort study phospholipid; biomarker; cognitive decline risk; cohort study

Share and Cite

MDPI and ACS Style

Liu, T.-T.; Xie, J.-W.; Long, X.; Yu, X.-C.; Jia, S.-S.; Man, Q.-Q.; Li, J.; Quan, P.-J.; Shan, K.-C.; Zhang, J.; et al. Plasma Phospholipid Biomarkers Related to the Risk of Cognitive Decline in the Elderly: Results from a Cohort Study. Nutrients 2026, 18, 185. https://doi.org/10.3390/nu18020185

AMA Style

Liu T-T, Xie J-W, Long X, Yu X-C, Jia S-S, Man Q-Q, Li J, Quan P-J, Shan K-C, Zhang J, et al. Plasma Phospholipid Biomarkers Related to the Risk of Cognitive Decline in the Elderly: Results from a Cohort Study. Nutrients. 2026; 18(2):185. https://doi.org/10.3390/nu18020185

Chicago/Turabian Style

Liu, Ting-Ting, Jia-Wei Xie, Xin Long, Xin-Can Yu, Shan-Shan Jia, Qing-Qing Man, Jing Li, Pu-Jun Quan, Ke-Chang Shan, Jian Zhang, and et al. 2026. "Plasma Phospholipid Biomarkers Related to the Risk of Cognitive Decline in the Elderly: Results from a Cohort Study" Nutrients 18, no. 2: 185. https://doi.org/10.3390/nu18020185

APA Style

Liu, T.-T., Xie, J.-W., Long, X., Yu, X.-C., Jia, S.-S., Man, Q.-Q., Li, J., Quan, P.-J., Shan, K.-C., Zhang, J., Song, S., & Liu, D. (2026). Plasma Phospholipid Biomarkers Related to the Risk of Cognitive Decline in the Elderly: Results from a Cohort Study. Nutrients, 18(2), 185. https://doi.org/10.3390/nu18020185

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop