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Nutrients
Volume 16
Issue 23
10.3390/nu16234224
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Article

Ameliorating Effect of Fermented Perilla frutescens on Sleep Deprivation-Induced Cognitive Impairment Through Antioxidant and BDNF Signaling in Mice

by
Chae-Ryeong Seo
1,†,
Bo Kyung Lee
1,†,
Hye Jin Jee
1,
Jae Ryeong Yoo
1,
Chul-Kyu Lee
2,
Jin Wook Park
2 and
Yi-Sook Jung
1,3,*
1
Department of Pharmacy, Ajou University, Suwon 16499, Republic of Korea
2
Headquarters of New Drug Development Support, Corestemchemon Inc., 15 F, Gyeonggi Bio Center, Suwon 16229, Republic of Korea
3
Research Institute of Pharmaceutical Sciences and Technology, Ajou University, Suwon 16499, Republic of Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2024, 16(23), 4224; https://doi.org/10.3390/nu16234224
Submission received: 2 September 2024 / Revised: 3 December 2024 / Accepted: 5 December 2024 / Published: 6 December 2024
(This article belongs to the Section Phytochemicals and Human Health)
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Abstract

Background: Adequate sleep is essential for maintaining cognitive function, as evidenced by literature. Perilla frutescens var. acuta Kudo (PF) is a traditional medicinal herb reported to improve vascular cognitive impairment and induce sedation. However, the effects of PF on cognitive impairment caused by sleep deprivation (SD) have not yet been evaluated. This study aims to evaluate the effects of fermented PF (FPF) and its underlying mechanisms in a model of SD-induced cognitive impairment. Methods: Mice were subjected to SD to establish cognitive impairment, and FPF was administered once daily for 3 days. Cognitive performance was assessed using Y-maze and passive avoidance tests, followed by molecular mechanisms analyses. Results: FPF treatment improved SD-induced cognitive impairment, as evidenced by increased spontaneous alternation and extended latency time. Histological analysis revealed that SD impaired the hippocampus, and this impairment was alleviated by FPF treatment. FPF demonstrated antioxidant activity by increasing glutathione levels and decreasing malondialdehyde levels. Furthermore, the decreased levels of brain-derived neurotrophic factor (BDNF) observed in sleep-deprived mice were restored with FPF treatment. FPF also enhanced the phosphorylation of tropomyosin receptor kinase B, extracellular signal-regulated kinase, and cAMP response element-binding protein. Conclusions: These results indicate that FPF may have beneficial effects on SD-induced cognitive impairment by protecting against oxidative stress and increasing BDNF expression.
Keywords: Perilla frutescens; fermentation; cognitive impairment; sleep-deprivation; oxidative stress; brain-derived neurotrophic factor Perilla frutescens; fermentation; cognitive impairment; sleep-deprivation; oxidative stress; brain-derived neurotrophic factor
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MDPI and ACS Style

Seo, C.-R.; Lee, B.K.; Jee, H.J.; Yoo, J.R.; Lee, C.-K.; Park, J.W.; Jung, Y.-S. Ameliorating Effect of Fermented Perilla frutescens on Sleep Deprivation-Induced Cognitive Impairment Through Antioxidant and BDNF Signaling in Mice. Nutrients 2024, 16, 4224. https://doi.org/10.3390/nu16234224

AMA Style

Seo C-R, Lee BK, Jee HJ, Yoo JR, Lee C-K, Park JW, Jung Y-S. Ameliorating Effect of Fermented Perilla frutescens on Sleep Deprivation-Induced Cognitive Impairment Through Antioxidant and BDNF Signaling in Mice. Nutrients. 2024; 16(23):4224. https://doi.org/10.3390/nu16234224

Chicago/Turabian Style

Seo, Chae-Ryeong, Bo Kyung Lee, Hye Jin Jee, Jae Ryeong Yoo, Chul-Kyu Lee, Jin Wook Park, and Yi-Sook Jung. 2024. "Ameliorating Effect of Fermented Perilla frutescens on Sleep Deprivation-Induced Cognitive Impairment Through Antioxidant and BDNF Signaling in Mice" Nutrients 16, no. 23: 4224. https://doi.org/10.3390/nu16234224

APA Style

Seo, C.-R., Lee, B. K., Jee, H. J., Yoo, J. R., Lee, C.-K., Park, J. W., & Jung, Y.-S. (2024). Ameliorating Effect of Fermented Perilla frutescens on Sleep Deprivation-Induced Cognitive Impairment Through Antioxidant and BDNF Signaling in Mice. Nutrients, 16(23), 4224. https://doi.org/10.3390/nu16234224

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