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Article

Aging-Related Behavioral, Adiposity, and Glucose Impairments and Their Association following Prenatal Alcohol Exposure in the C57BL/6J Mouse

1
UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA
2
Department of Nutrition, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Robert Colin Carter
Nutrients 2022, 14(7), 1438; https://doi.org/10.3390/nu14071438
Received: 9 March 2022 / Revised: 22 March 2022 / Accepted: 25 March 2022 / Published: 30 March 2022
People that experience prenatal alcohol exposure (PAE) may have behavioral and metabolic impairments, and it is unclear whether these remain stable or change with age. We assessed behavioral and metabolic endpoints across the lifespan in a mouse model of fetal alcohol spectrum disorder (FASD). Pregnant C57BL/6J mice received alcohol (ALC; 3 g/kg) or maltose-dextrin (control, CON) daily from embryonic day 8.5 to 17.5. Offspring were tested on accelerating rotarod, Y-maze, novel object recognition, and fear conditioning at 6 weeks and 10 and 17 months; females were also tested at 24 months. Body composition, fasting glucose, and glucose clearance were assessed at 18 months. Female but not male ALC mice had greater adiposity than age-matched CON from 7 months onward. At 18 months, male but not female ALC mice had reduced glucose clearance and ALC mice were more likely to have elevated fasting glucose. In the rotarod training session, ALC females performed worse than CON. In the Y-maze, significant exposure-age interactions affected ALC performance in both sexes versus age-match CON. For fear conditioning, all animals acquired the task and froze more at older ages. In both the context and cued tasks, there were exposure-age interactions and ALC animals frozen less than CON at 10 months. Correlation analysis revealed that fasting glucose and glucose clearance correlated with % of body fat in ALC but not in CON mice. Additionally, glucose intolerance and % body fat negatively correlated with performance in the rotarod, context learning, and novel object recognition tasks in ALC but not CON mice. All mice exhibit worsening of behavioral performance as they age, and PAE did not further exacerbate this. ALC but not CON mice displayed adiposity and glucose intolerance that correlate with their cognitive impairments, suggesting that these may be mechanistically related in PAE. Findings emphasize that FASD should be considered a whole-body disorder. View Full-Text
Keywords: fetal alcohol syndrome; metabolic syndrome; aging; glucose tolerance; developmental origins of health and disease; cognitive performance fetal alcohol syndrome; metabolic syndrome; aging; glucose tolerance; developmental origins of health and disease; cognitive performance
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MDPI and ACS Style

Smith, S.M.; Pjetri, E.; Friday, W.B.; Presswood, B.H.; Ricketts, D.K.; Walter, K.R.; Mooney, S.M. Aging-Related Behavioral, Adiposity, and Glucose Impairments and Their Association following Prenatal Alcohol Exposure in the C57BL/6J Mouse. Nutrients 2022, 14, 1438. https://doi.org/10.3390/nu14071438

AMA Style

Smith SM, Pjetri E, Friday WB, Presswood BH, Ricketts DK, Walter KR, Mooney SM. Aging-Related Behavioral, Adiposity, and Glucose Impairments and Their Association following Prenatal Alcohol Exposure in the C57BL/6J Mouse. Nutrients. 2022; 14(7):1438. https://doi.org/10.3390/nu14071438

Chicago/Turabian Style

Smith, Susan M., Eneda Pjetri, Walter B. Friday, Brandon H. Presswood, Dane K. Ricketts, Kathleen R. Walter, and Sandra M. Mooney. 2022. "Aging-Related Behavioral, Adiposity, and Glucose Impairments and Their Association following Prenatal Alcohol Exposure in the C57BL/6J Mouse" Nutrients 14, no. 7: 1438. https://doi.org/10.3390/nu14071438

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