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Targeting Cardiovascular Diseases by Flavonols: An Update

Department of Social Medicine and Public Health, Medical University of Warsaw, Oczki Str. 3, 02-007 Warsaw, Poland
Department of Clinical Dietetics, Faculty of Health Sciences, Medical University of Warsaw, E Ciołka Str. 27, 01-445 Warsaw, Poland
Author to whom correspondence should be addressed.
Academic Editor: Přemysl Mladěnka
Nutrients 2022, 14(7), 1439;
Received: 23 February 2022 / Revised: 24 March 2022 / Accepted: 28 March 2022 / Published: 30 March 2022
Flavonols are one of the most plentiful flavonoid subclasses found in natural products and are extensively used as dietary supplements. Numerous in vitro and in vivo studies have shown the cardioprotective properties of flavonols, especially quercetin. This group of substances exerts positive impacts primarily due to their antiatherogenic, antithrombotic, and antioxidant activities. The potential of flavonols to promote vasodilation and regulation of apoptotic processes in the endothelium are other beneficial effects on the cardiovascular system. Despite promising experimental findings, randomized controlled trials and meta-analyses have yielded inconsistent results on the influence of these substances on human cardiovascular parameters. Thus, this review aims to summarize the most recent clinical data on the intake of these substances and their effects on the cardiovascular system. The present study will help clinicians and other healthcare workers understand the value of flavonol supplementation in both subjects at risk for cardiovascular disease and patients with cardiovascular diseases. View Full-Text
Keywords: flavonols; quercetin; cardiovascular diseases; inflammation flavonols; quercetin; cardiovascular diseases; inflammation
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MDPI and ACS Style

Kozłowska, A.; Szostak-Węgierek, D. Targeting Cardiovascular Diseases by Flavonols: An Update. Nutrients 2022, 14, 1439.

AMA Style

Kozłowska A, Szostak-Węgierek D. Targeting Cardiovascular Diseases by Flavonols: An Update. Nutrients. 2022; 14(7):1439.

Chicago/Turabian Style

Kozłowska, Aleksandra, and Dorota Szostak-Węgierek. 2022. "Targeting Cardiovascular Diseases by Flavonols: An Update" Nutrients 14, no. 7: 1439.

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