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Review

Colostrum Therapy for Human Gastrointestinal Health and Disease

by 1 and 1,2,*
1
Tropical Gastroenterology & Nutrition Group, University of Zambia School of Medicine, Lusaka 10101, Zambia
2
Blizard Institute, Barts & The London School of Medicine, Queen Mary University of London, London E1 2AT, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Francisco J. Pérez-Cano
Nutrients 2021, 13(6), 1956; https://doi.org/10.3390/nu13061956
Received: 26 March 2021 / Revised: 12 May 2021 / Accepted: 1 June 2021 / Published: 7 June 2021
(This article belongs to the Special Issue The Use of Bovine Colostrum in Medical Practice and Human Health)
There is increasing awareness that a broad range of gastrointestinal diseases, and some systemic diseases, are characterized by failure of the mucosal barrier. Bovine colostrum is a complex biological fluid replete with growth factors, nutrients, hormones, and paracrine factors which have a range of properties likely to contribute to mucosal healing in a wide range of infective, inflammatory, and injury conditions. In this review, we describe the anatomy and physiology of the intestinal barrier and how it may fail. We survey selected diseases in which disordered barrier function contributes to disease pathogenesis or progression, and review the evidence for or against efficacy of bovine colostrum in management. These disorders include enteropathy due to non-steroidal anti-inflammatory drugs (NSAIDs), inflammatory bowel disease (IBD), necrotizing enterocolitis, infectious diarrhea, intestinal failure, and damage due to cancer therapy. In animal models, bovine colostrum benefits NSAID enteropathy, IBD, and intestinal failure. In human trials, there is substantial evidence of efficacy of bovine colostrum in inflammatory bowel disease and in infectious diarrhea. Given the robust scientific rationale for using bovine colostrum as a promoter of mucosal healing, further work is needed to define its role in therapy. View Full-Text
Keywords: colostrum; diarrhea; inflammatory bowel disease; enteropathy; mucosal healing colostrum; diarrhea; inflammatory bowel disease; enteropathy; mucosal healing
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MDPI and ACS Style

Chandwe, K.; Kelly, P. Colostrum Therapy for Human Gastrointestinal Health and Disease. Nutrients 2021, 13, 1956. https://doi.org/10.3390/nu13061956

AMA Style

Chandwe K, Kelly P. Colostrum Therapy for Human Gastrointestinal Health and Disease. Nutrients. 2021; 13(6):1956. https://doi.org/10.3390/nu13061956

Chicago/Turabian Style

Chandwe, Kanta, and Paul Kelly. 2021. "Colostrum Therapy for Human Gastrointestinal Health and Disease" Nutrients 13, no. 6: 1956. https://doi.org/10.3390/nu13061956

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