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Open AccessArticle

Effects of Acute Cocoa Supplementation on Postprandial Apolipoproteins, Lipoprotein Subclasses, and Inflammatory Biomarkers in Adults with Type 2 Diabetes after a High-Fat Meal

1
Department of Kinesiology and Nutrition Sciences, School of Integrated Health Sciences, University of Nevada, Las Vegas, NV 89154, USA
2
Division of Endocrinology, Medical University of South Carolina, Charleston, SC 29245, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(7), 1902; https://doi.org/10.3390/nu12071902
Received: 5 June 2020 / Revised: 22 June 2020 / Accepted: 24 June 2020 / Published: 27 June 2020
(This article belongs to the Special Issue Health-Promoting Components of Foods in Human Health)
Dyslipidemia and inflammation exacerbate postprandial metabolic stress in people with diabetes. Acute dietary supplementation with polyphenols shows promise in improving postprandial metabolic stress in type 2 diabetes (T2D). Cocoa is a rich source of dietary polyphenols with demonstrated cardioprotective effects in adults without diabetes. To date, the acute effects of cocoa on postprandial lipids and inflammation have received little attention in the presence of T2D. This report expands on our earlier observation that polyphenol-rich cocoa, given as a beverage with a fast-food-style, high-fat breakfast, increased postprandial high-density lipoprotein-cholesterol (HDL-C) in adults with T2D. We now test whether polyphenol-rich cocoa modulated postprandial apolipoproteins (Apo-A1, B), non-esterified fatty acids, nuclear magnetic resonance (NMR)-derived lipoprotein subclass profiles, and select biomarkers of inflammation following the same dietary challenge. We found that cocoa decreased NMR-derived concentrations of total very low-density lipoprotein and chylomicron particles and increased the concentration of total HDL particles over the 6-hour postprandial phase. Serum interleukin-18 was decreased by cocoa vs. placebo. Thus, polyphenol-rich cocoa may alleviate postprandial dyslipidemia and inflammation following a high-fat dietary challenge in adults with T2D. The study was registered at clinicaltrials.gov as NCT01886989. View Full-Text
Keywords: phytochemicals; functional food; dietary polyphenols; flavonoids; catechins; dyslipidemia; nutraceuticals; inflammation; chronic disease phytochemicals; functional food; dietary polyphenols; flavonoids; catechins; dyslipidemia; nutraceuticals; inflammation; chronic disease
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MDPI and ACS Style

Davis, D.W.; Tallent, R.; Navalta, J.W.; Salazar, A.; Lyons, T.J.; Basu, A. Effects of Acute Cocoa Supplementation on Postprandial Apolipoproteins, Lipoprotein Subclasses, and Inflammatory Biomarkers in Adults with Type 2 Diabetes after a High-Fat Meal. Nutrients 2020, 12, 1902. https://doi.org/10.3390/nu12071902

AMA Style

Davis DW, Tallent R, Navalta JW, Salazar A, Lyons TJ, Basu A. Effects of Acute Cocoa Supplementation on Postprandial Apolipoproteins, Lipoprotein Subclasses, and Inflammatory Biomarkers in Adults with Type 2 Diabetes after a High-Fat Meal. Nutrients. 2020; 12(7):1902. https://doi.org/10.3390/nu12071902

Chicago/Turabian Style

Davis, Dustin W.; Tallent, Rickelle; Navalta, James W.; Salazar, Anthony; Lyons, Timothy J.; Basu, Arpita. 2020. "Effects of Acute Cocoa Supplementation on Postprandial Apolipoproteins, Lipoprotein Subclasses, and Inflammatory Biomarkers in Adults with Type 2 Diabetes after a High-Fat Meal" Nutrients 12, no. 7: 1902. https://doi.org/10.3390/nu12071902

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