Next Article in Journal
Neutral Human Milk Oligosaccharides Are Associated with Multiple Fixed and Modifiable Maternal and Infant Characteristics
Next Article in Special Issue
The Relationship between Body Composition and Muscle Tone in Children with Cerebral Palsy: A Case-Control Study
Previous Article in Journal
Influence of Maternal Milk on the Neonatal Intestinal Microbiome
Previous Article in Special Issue
Reference Values for Skeletal Muscle Mass – Current Concepts and Methodological Considerations
Open AccessArticle

Dietary Factors in Relation to Liver Fat Content: A Cross-sectional Study

German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
Medical Faculty, Heidelberg University, 69120 Heidelberg, Germany
Huntsman Cancer Institute and University of Utah, Department of Population Health Sciences, Salt Lake City, UT 84112-5550, USA
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(3), 825;
Received: 27 February 2020 / Revised: 15 March 2020 / Accepted: 16 March 2020 / Published: 20 March 2020
(This article belongs to the Special Issue Nutrition, Metabolic Status, and Body Composition)
Non-alcoholic fatty liver disease (NAFLD) can lead to functional liver impairment and severe comorbidities. Beyond energy balance, several dietary factors may increase NAFLD risk, but human studies are lacking. The aim of this cross-sectional study was to investigate the associations between food consumption (47 food groups, derived Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diet quality scores) and liver fat content (continuous scale and NAFLD, i.e., >5% liver fat content). Liver fat content was measured by magnetic resonance imaging (MRI) in 136 individuals (BMI: 25–40 kg/m2, age: 35–65, 50.7% women) and food intake was recorded by food frequency questionnaires (FFQs). Associations between food items and liver fat were evaluated by multi-variable regression models. Intakes of cake and cookies as well legumes were inversely associated with liver fat content, while positive associations with intakes of high-fat dairy and cheese were observed. Only cake and cookie intake also showed an inverse association with NAFLD. This inverse association was unexpected, but not affected by adjustment for reporting bias. Both diet quality scores were inversely associated with liver fat content and NAFLD. Thus, as smaller previous intervention studies, our results suggest that higher diet quality is related to lower liver fat, but larger trials with iso-caloric interventions are needed to corroborate these findings. View Full-Text
Keywords: non-alcoholic fatty liver disease; NAFLD; Mediterranean diet; DASH diet; food groups; MRI non-alcoholic fatty liver disease; NAFLD; Mediterranean diet; DASH diet; food groups; MRI
MDPI and ACS Style

Watzinger, C.; Nonnenmacher, T.; Grafetstätter, M.; Sowah, S.A.; Ulrich, C.M.; Kauczor, H.-U.; Kaaks, R.; Schübel, R.; Nattenmüller, J.; Kühn, T. Dietary Factors in Relation to Liver Fat Content: A Cross-sectional Study. Nutrients 2020, 12, 825.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop