Next Article in Journal
Using the Internet: Nutrition Information-Seeking Behaviours of Lay People Enrolled in a Massive Online Nutrition Course
Next Article in Special Issue
Plasma Trans Fatty Acid Levels, Cardiovascular Risk Factors and Lifestyle: Results from the Akershus Cardiac Examination 1950 Study
Previous Article in Journal
Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters
Previous Article in Special Issue
Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis?
Open AccessArticle

Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation on Plasma Lipids and Lipoproteins in Normolipidemic Adults

1
Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892-1666, USA
2
Clinical Center, Department of Laboratory Medicine, NIH, Bethesda, MD 20814, USA
3
Clinical Center, Nutrition Department, NIH, Bethesda, MD 20814, USA
4
Saha Cardiovascular Research Center and Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40506, USA
5
Proteomics Core, Cardiovascular Branch, NHLBI, NIH, Bethesda, MD 20814, USA
6
Section of Inflammation and Cardiometabolic Diseases, Cardiovascular Branch, NHLBI, NIH, Bethesda, MD 20814, USA
7
Office of Biostatistics Research, NHLBI, NIH, Bethesda, MD 20814, USA
*
Authors to whom correspondence should be addressed.
Z.-H.Y. and M.A. contributed equally.
Nutrients 2020, 12(3), 749; https://doi.org/10.3390/nu12030749
Received: 13 February 2020 / Revised: 5 March 2020 / Accepted: 8 March 2020 / Published: 12 March 2020
(This article belongs to the Special Issue Polyunsaturated Fatty Acids Intake and Human Health)
Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have both shared and different cardiovascular effects, and commonly used fish oil supplements have considerably varied EPA/DHA ratios. Aims: We compared the effects of fish oil supplements with different EPA/DHA ratios on lipoprotein metabolism. Methods: In a double-blind, randomized cross-over study, normolipidemic adults (n = 30) consumed 12 g/day of EPA-rich (EPA/DHA: 2.3) or DHA-rich (EPA/DHA: 0.3) fish oil for 8-weeks, separated by an 8-week washout period. Results: Both fish oil supplements similarly lowered plasma TG levels and TG-related NMR parameters versus baseline (p < 0.05). There were no changes in plasma cholesterol-related parameters due to either fish oil, although on-treatment levels for LDL particle number were slightly higher for DHA-rich oil compared with EPA-rich oil (p < 0.05). Both fish oil supplements similarly altered HDL subclass profile and proteome, and down regulated HDL proteins related to inflammation, with EPA-rich oil to a greater extent. Furthermore, EPA-rich oil increased apoM abundance versus DHA-rich oil (p < 0.05). Conclusions: Overall, fish oil supplements with varied EPA/DHA ratios had similar effects on total lipids/lipoproteins, but differences were observed in lipoprotein subfraction composition and distribution, which could impact on the use of EPA versus DHA for improving cardiovascular health. View Full-Text
Keywords: eicosapentaenoic acid (EPA); docosahexaenoic acid (DHA); omega-3 fatty acids; lipoprotein metabolism; triglyceride; LDL cholesterol; HDL cholesterol eicosapentaenoic acid (EPA); docosahexaenoic acid (DHA); omega-3 fatty acids; lipoprotein metabolism; triglyceride; LDL cholesterol; HDL cholesterol
Show Figures

Figure 1

MDPI and ACS Style

Yang, Z.-H.; Amar, M.; Sampson, M.; Courville, A.B.; Sorokin, A.V.; Gordon, S.M.; Aponte, A.M.; Stagliano, M.; Playford, M.P.; Fu, Y.-P.; Yang, S.; Mehta, N.N.; Remaley, A.T. Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation on Plasma Lipids and Lipoproteins in Normolipidemic Adults. Nutrients 2020, 12, 749. https://doi.org/10.3390/nu12030749

AMA Style

Yang Z-H, Amar M, Sampson M, Courville AB, Sorokin AV, Gordon SM, Aponte AM, Stagliano M, Playford MP, Fu Y-P, Yang S, Mehta NN, Remaley AT. Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation on Plasma Lipids and Lipoproteins in Normolipidemic Adults. Nutrients. 2020; 12(3):749. https://doi.org/10.3390/nu12030749

Chicago/Turabian Style

Yang, Zhi-Hong; Amar, Marcelo; Sampson, Maureen; Courville, Amber B.; Sorokin, Alexander V.; Gordon, Scott M.; Aponte, Angel M.; Stagliano, Michael; Playford, Martin P.; Fu, Yi-Ping; Yang, Shanna; Mehta, Nehal N.; Remaley, Alan T. 2020. "Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation on Plasma Lipids and Lipoproteins in Normolipidemic Adults" Nutrients 12, no. 3: 749. https://doi.org/10.3390/nu12030749

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop