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Open AccessArticle

The Use of Vitamins and Coenzyme Q10 for the Treatment of Vascular Occlusion Diseases Affecting the Retina

1
Instituto Oftalmológico Fernández-Vega, Avda. Dres. Fernández-Vega, 34, 33012 Oviedo, Spain
2
Instituto Universitario Fernández-Vega (Fundación de Investigación Oftalmológica, Universidad de Oviedo), 33012 Oviedo, Spain
3
Departamento de Morfología y Biología Celular, Grupo SINPOS, Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, Avda. Julián Clavería, 6, 33006 Oviedo, Spain
4
Hospital Universitario de Cabueñes, Los Prados, 395, 33394 Gijón, Spain
5
Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Calle Magdalena Vicuña 1281, 8900000 Santiago de Chile, Chile
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(3), 723; https://doi.org/10.3390/nu12030723
Received: 21 January 2020 / Revised: 4 March 2020 / Accepted: 6 March 2020 / Published: 9 March 2020
(This article belongs to the Special Issue Nutrition for Eye Health)
Nutritional supplementation with antioxidants and vitamins is widely recommended in the treatment of vascular disorders affecting the retina, although there is insufficient evidence on its effectiveness. The vitamin-like compound coenzyme Q10 (CoQ10) is a nutritional supplement of current interest to treat neurodegenerative diseases. Here, we report a retrospective clinical case series study of 48 patients diagnosed with retinal vascular diseases, including non-arteritic ischemic optic neuropathy (NAION), retinal artery occlusion (RAO), and homonymous hemianopia or quadrantanopia following stroke, treated with oral supplementation with CoQ10 (100 mg per day) and vitamins. Patient follow-up was performed using the Humphrey field analyzer and 30-2 testing algorithm to determine the visual field index (VFI) and progression rates. All treated patients showed positive VFI progression rates per year: +11.5 ± 15% for NAION patients (n = 18), +22 ± 17% for RAO patients (n = 7), +9.3 ± 10.5% for hemianopia/quadrantanopia patients (n = 10), and +11 ± 21% for patients with other conditions (n = 13). The interruption of CoQ10 supplementation in one patient resulted in a pronounced decrease of the VFI, which was partially recovered when treatment was restored. This study supports the role of CoQ10 as a nutritional therapeutic agent for vascular diseases affecting the retina. Owing to decreased VFI after interruption of CoQ10, its beneficial effects may be reversible. View Full-Text
Keywords: Vascular diseases; retina; visual field defects; dietary supplementation; vitamins; coenzyme Q10 Vascular diseases; retina; visual field defects; dietary supplementation; vitamins; coenzyme Q10
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MDPI and ACS Style

Fernández-Vega, B.; Nicieza, J.; Álvarez-Barrios, A.; Álvarez, L.; García, M.; Fernández-Vega, C.; Vega, J.A.; González-Iglesias, H. The Use of Vitamins and Coenzyme Q10 for the Treatment of Vascular Occlusion Diseases Affecting the Retina. Nutrients 2020, 12, 723.

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