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Open AccessFeature PaperReview

Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review

1
Department of Rheumatology, CHU Lille, Université de Lille, F-59000 Lille, France
2
Department of Rheumatology, CHU de Montpellier, Montpellier University, 34295 Montpellier, France
3
Department of Internal Medicine, Hôpital Beaujon, AP-HP Nord, Université de Paris, F-92100 Clichy, France
4
Department of Rheumatology, Hôpital Avicenne, AP-HP, INSERM U1125, Université Paris 13, F-93017 Bobigny, France
5
Department of Nutrition, Specialized Obesity Center, Hôpital Européen Georges Pompidou, Université de Paris, AP-HP, F-75015 Paris, France
6
Epidemiology and Biostatistics Sorbonne Paris City Center, UMR1153, Institut National de la Santé et de la Recherche Médicale, F-75004 Paris, France
7
DMU 3ID, Hôpital Saint Antoine, AP-HP, CRSA Inserm UMRS_938, Sorbonne Université, F-75012 Paris, France
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3800; https://doi.org/10.3390/nu12123800
Received: 22 November 2020 / Revised: 7 December 2020 / Accepted: 8 December 2020 / Published: 11 December 2020
(This article belongs to the Special Issue Diet and Rheumatoid Arthritis)
Background: Spices, i.e., curcumin, ginger, saffron, and cinnamon, have a thousand-year history of medicinal use in Asia. Modern medicine has begun to explore their therapeutic properties during the last few decades. We aimed to perform a systematic literature review (SLR) of randomized controlled trials (RCTs) assessing the effect of spice supplementation on symptoms and disease activity in patients with chronic inflammatory rheumatic diseases (rheumatoid arthritis (RA), spondylarthritis, or psoriatic arthritis). Methods: An SLR of RCTs, reviews, and meta-analyses was performed, searching for articles in MEDLINE/PubMed. Abstracts from international rheumatology and nutrition congresses (2017–2020) were also scrutinized. The risk of bias of the selected studies was evaluated using the Cochrane Collaboration’s tool and the Jadad scale. Results: Altogether, six studies, assessing the use of spice supplementation only in RA patients, were included: one on garlic supplementation, two on curcumin, one on ginger, one on cinnamon, and one on saffron supplementation. Garlic, ginger, cinnamon, or saffron supplementation was associated with a decrease in RA clinical activity. However, several points limit the external validity of these studies. No conclusion on the impact of curcumin supplementation on RA activity could be drawn due to low-quality studies. Conclusions: Garlic, ginger, cinnamon, and saffron supplementation could have a beneficial effect on RA activity, but the risk of bias of these studies is difficult to assess and data are too limited to recommend them in daily practice. View Full-Text
Keywords: rheumatoid arthritis; spice; garlic; cinnamon; curcuma; saffron; ginger; disease activity rheumatoid arthritis; spice; garlic; cinnamon; curcuma; saffron; ginger; disease activity
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MDPI and ACS Style

Letarouilly, J.-G.; Sanchez, P.; Nguyen, Y.; Sigaux, J.; Czernichow, S.; Flipo, R.-M.; Sellam, J.; Daïen, C. Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review. Nutrients 2020, 12, 3800. https://doi.org/10.3390/nu12123800

AMA Style

Letarouilly J-G, Sanchez P, Nguyen Y, Sigaux J, Czernichow S, Flipo R-M, Sellam J, Daïen C. Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review. Nutrients. 2020; 12(12):3800. https://doi.org/10.3390/nu12123800

Chicago/Turabian Style

Letarouilly, Jean-Guillaume; Sanchez, Pauline; Nguyen, Yann; Sigaux, Johanna; Czernichow, Sébastien; Flipo, René-Marc; Sellam, Jérémie; Daïen, Claire. 2020. "Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review" Nutrients 12, no. 12: 3800. https://doi.org/10.3390/nu12123800

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